IL-6 Enhances the Viability and Invasion Ability of Prostate Cancer Cells
Prostate cancer is a slow-growing cancer whose incidence increases with age. IL-6 expression is significantly increased in a variety of malignant tumor stroma, which is a key factor involved in the association between inflammation and tumor. So as to investigate how prostate cancer works, recombinant IL-6 was used to stimulate human prostate cancer cells (PC-3). After treatment for 24,48,72h, the viability of cancer cells was detected by CCK-8 experiment. The effect of recombinant IL-6 on the invasion of prostate cancer cells was analyzed by Transwell experiment. The results showed that IL-6 can increase the viability of prostate cancer cells and facilitate the invasion of prostate cancer cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:308 |
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| Enthalten in: |
Studies in health technology and informatics - 308(2023) vom: 23. Nov., Seite 521-526 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cheng, Kai [VerfasserIn] |
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| Links: |
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| Themen: |
Cell invasion |
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| Anmerkungen: |
Date Completed 30.11.2023 Date Revised 30.11.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/SHTI230879 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364989939 |
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| 520 | |a Prostate cancer is a slow-growing cancer whose incidence increases with age. IL-6 expression is significantly increased in a variety of malignant tumor stroma, which is a key factor involved in the association between inflammation and tumor. So as to investigate how prostate cancer works, recombinant IL-6 was used to stimulate human prostate cancer cells (PC-3). After treatment for 24,48,72h, the viability of cancer cells was detected by CCK-8 experiment. The effect of recombinant IL-6 on the invasion of prostate cancer cells was analyzed by Transwell experiment. The results showed that IL-6 can increase the viability of prostate cancer cells and facilitate the invasion of prostate cancer cells | ||
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