Chagas disease stroke and associated risk factors : A case-control study
Copyright © 2023 Elsevier Inc. All rights reserved..
INTRODUCTION: The intricate relationship between Chagas disease and ischemic stroke remains unclear. Limited evidence exists concerning secondary prophylaxis, etiological diagnosis, and stroke-related determinants. This study aims to discern factors linked to stroke in Chagas disease by contrasting patients with and without a history of ischemic stroke.
METHODS: Retrospective data from all outpatient Chagas disease patients from two Brazilian hospitals - one Chagas center and one stroke clinic - were examined. Descriptive analyses were conducted to identify stroke-associated factors. Variables were compared between patients with and without ischemic stroke history.
RESULTS: Among 678 subjects, 72 had experienced stroke. Univariate associations with stroke included male gender, heart failure, prior or ongoing alcoholism, electrocardiographic features (non-sinus rhythm, left bundle branch, right bundle branch block, left anterosuperior fascicular block, atrial fibrillation), as well as echocardiographic findings indicative of reduced left ventricular ejection fraction and segmental abnormalities. After logistic regression (multivariate analysis), congestive heart failure, right bundle branch block, left anterosuperior divisional block, and atrial fibrillation retained independent associations.
CONCLUSION: In this study, cardiac involvement emerged as the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors were prevalent, their influence on ischemic stroke in Chagas disease appeared limited.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
---|---|
Enthalten in: |
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 33(2024), 1 vom: 15. Jan., Seite 107463 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
de Melo, Eduardo Sousa [VerfasserIn] |
---|
Links: |
---|
Themen: |
Atherosclerosis |
---|
Anmerkungen: |
Date Completed 01.01.2024 Date Revised 01.01.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.jstrokecerebrovasdis.2023.107463 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364979852 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM364979852 | ||
003 | DE-627 | ||
005 | 20240108140821.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.jstrokecerebrovasdis.2023.107463 |2 doi | |
028 | 5 | 2 | |a pubmed24n1246.xml |
035 | |a (DE-627)NLM364979852 | ||
035 | |a (NLM)38006768 | ||
035 | |a (PII)S1052-3057(23)00485-8 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a de Melo, Eduardo Sousa |e verfasserin |4 aut | |
245 | 1 | 0 | |a Chagas disease stroke and associated risk factors |b A case-control study |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 01.01.2024 | ||
500 | |a Date Revised 01.01.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
520 | |a INTRODUCTION: The intricate relationship between Chagas disease and ischemic stroke remains unclear. Limited evidence exists concerning secondary prophylaxis, etiological diagnosis, and stroke-related determinants. This study aims to discern factors linked to stroke in Chagas disease by contrasting patients with and without a history of ischemic stroke | ||
520 | |a METHODS: Retrospective data from all outpatient Chagas disease patients from two Brazilian hospitals - one Chagas center and one stroke clinic - were examined. Descriptive analyses were conducted to identify stroke-associated factors. Variables were compared between patients with and without ischemic stroke history | ||
520 | |a RESULTS: Among 678 subjects, 72 had experienced stroke. Univariate associations with stroke included male gender, heart failure, prior or ongoing alcoholism, electrocardiographic features (non-sinus rhythm, left bundle branch, right bundle branch block, left anterosuperior fascicular block, atrial fibrillation), as well as echocardiographic findings indicative of reduced left ventricular ejection fraction and segmental abnormalities. After logistic regression (multivariate analysis), congestive heart failure, right bundle branch block, left anterosuperior divisional block, and atrial fibrillation retained independent associations | ||
520 | |a CONCLUSION: In this study, cardiac involvement emerged as the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors were prevalent, their influence on ischemic stroke in Chagas disease appeared limited | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Atherosclerosis | |
650 | 4 | |a Chagas Disease | |
650 | 4 | |a Chagas cardiomyopathy | |
650 | 4 | |a Embolic stroke | |
650 | 4 | |a Ischemic Stroke | |
700 | 1 | |a de Paiva Bezerra, Rodrigo |e verfasserin |4 aut | |
700 | 1 | |a de Holanda, Arthur Cesário |e verfasserin |4 aut | |
700 | 1 | |a Lira E Silva, Maria Júnia |e verfasserin |4 aut | |
700 | 1 | |a Travassos, Paloma Peter |e verfasserin |4 aut | |
700 | 1 | |a da Silva, Tayne Fernanda Lemos |e verfasserin |4 aut | |
700 | 1 | |a de Azevedo Oliveira, Gênova Maria |e verfasserin |4 aut | |
700 | 1 | |a Alves, Silvia Marinho Martins |e verfasserin |4 aut | |
700 | 1 | |a Medeiros, Carolina de Araújo |e verfasserin |4 aut | |
700 | 1 | |a da Silveira Barros, Maria das Neves Dantas |e verfasserin |4 aut | |
700 | 1 | |a de Oliveira, Wilson Alves |e verfasserin |4 aut | |
700 | 1 | |a Silva, Gisele Sampaio |e verfasserin |4 aut | |
700 | 1 | |a de Andrade Valença, Luciana Patrizia Alves |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association |d 1991 |g 33(2024), 1 vom: 15. Jan., Seite 107463 |w (DE-627)NLM090676726 |x 1532-8511 |7 nnns |
773 | 1 | 8 | |g volume:33 |g year:2024 |g number:1 |g day:15 |g month:01 |g pages:107463 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2023.107463 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 33 |j 2024 |e 1 |b 15 |c 01 |h 107463 |