Revisiting the Use of Normal Saline for Peritoneal Washing in Ovarian Cancer
The omentum is the predominant site of ovarian cancer metastasis, but it is difficult to remove the omentum in its entirety. There is a critical need for effective approaches that minimize the risk of colonization of preserved omental tissues by occult cancer cells. Normal saline (0.9% sodium chloride) is commonly used to wash the peritoneal cavity during ovarian cancer surgery. The omentum has a prodigious ability to absorb fluid in the peritoneal cavity, but the impact of normal saline on the omentum is poorly understood. In this review article, we discuss why normal saline is not a biocompatible solution, drawing insights from clinical investigations of normal saline in fluid resuscitation and from the cytopathologic evaluation of peritoneal washings. We integrate these insights with the unique biology of the omentum and omental metastasis, highlighting the importance of considering the absorptive ability of the omentum when administering agents into the peritoneal cavity. Furthermore, we describe insights from preclinical studies regarding the mechanisms by which normal saline might render the omentum conducive for colonization by cancer cells. Importantly, we discuss the possibility that the risk of colonization of preserved omental tissues might be minimized by using balanced crystalloid solutions for peritoneal washing.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
---|---|
Enthalten in: |
International journal of molecular sciences - 24(2023), 22 vom: 17. Nov. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Akasaka, Hironari [VerfasserIn] |
---|
Links: |
---|
Themen: |
Crystalloid solutions |
---|
Anmerkungen: |
Date Completed 27.11.2023 Date Revised 05.02.2024 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.3390/ijms242216449 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364948558 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM364948558 | ||
003 | DE-627 | ||
005 | 20240205231930.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/ijms242216449 |2 doi | |
028 | 5 | 2 | |a pubmed24n1281.xml |
035 | |a (DE-627)NLM364948558 | ||
035 | |a (NLM)38003636 | ||
035 | |a (PII)16449 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Akasaka, Hironari |e verfasserin |4 aut | |
245 | 1 | 0 | |a Revisiting the Use of Normal Saline for Peritoneal Washing in Ovarian Cancer |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.11.2023 | ||
500 | |a Date Revised 05.02.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The omentum is the predominant site of ovarian cancer metastasis, but it is difficult to remove the omentum in its entirety. There is a critical need for effective approaches that minimize the risk of colonization of preserved omental tissues by occult cancer cells. Normal saline (0.9% sodium chloride) is commonly used to wash the peritoneal cavity during ovarian cancer surgery. The omentum has a prodigious ability to absorb fluid in the peritoneal cavity, but the impact of normal saline on the omentum is poorly understood. In this review article, we discuss why normal saline is not a biocompatible solution, drawing insights from clinical investigations of normal saline in fluid resuscitation and from the cytopathologic evaluation of peritoneal washings. We integrate these insights with the unique biology of the omentum and omental metastasis, highlighting the importance of considering the absorptive ability of the omentum when administering agents into the peritoneal cavity. Furthermore, we describe insights from preclinical studies regarding the mechanisms by which normal saline might render the omentum conducive for colonization by cancer cells. Importantly, we discuss the possibility that the risk of colonization of preserved omental tissues might be minimized by using balanced crystalloid solutions for peritoneal washing | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a crystalloid solutions | |
650 | 4 | |a neoplasm metastasis | |
650 | 4 | |a omentum | |
650 | 4 | |a peritoneal cavity | |
650 | 4 | |a peritoneal lavage | |
650 | 4 | |a tumor microenvironment | |
650 | 7 | |a Saline Solution |2 NLM | |
700 | 1 | |a Naora, Honami |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d 2008 |g 24(2023), 22 vom: 17. Nov. |w (DE-627)NLM185552161 |x 1422-0067 |7 nnns |
773 | 1 | 8 | |g volume:24 |g year:2023 |g number:22 |g day:17 |g month:11 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/ijms242216449 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 24 |j 2023 |e 22 |b 17 |c 11 |