Biomarkers for Monitoring of Changes in Disease Activity in Ulcerative Colitis
BACKGROUND: In recent years, various biomarkers of ulcerative colitis (UC) have emerged; however, few studies have simultaneously examined the utility of multiple biomarkers for monitoring disease activity. Additionally, serum leucine-rich alpha-2 glycoprotein (LRG), a new biomarker, may show a blunt response to anti-TNF antibody therapy. This prospective study explored effective biomarkers that could monitor disease activity changes in patients with UC. In addition, we examined the effect of anti-TNF antibody therapy on changes in LRG.
METHODS: Blood and stool samples were collected twice from patients with UC: at baseline and at least 8 weeks later. Changes in serum LRG, interleukin (IL)-6, prealbumin (pre-Alb), high-sensitivity C-reactive protein (hs-CRP), CRP, and fecal calprotectin (FC) were measured and correlated with changes in disease activity. The relationship between anti-TNF antibody therapy and LRG levels was also examined in patients with the same disease activity.
RESULTS: Forty-eight patients with UC (96 samples) were analyzed. ΔLRG and ΔIL-6 correlated strongly with the change in the partial Mayo (pMayo) score between the two time points (ΔpMayo) (r = 0.686, 0.635, respectively). In contrast, FC and IL-6 were particularly accurate predictors of clinical remission, and their area under the curves (AUCs) were significantly higher than that of CRP (AUC: 0.81, 0.76 vs. 0.50; p = 0.001, 0.005). No association was found between the administration of anti-TNF antibody preparations and the LRG values.
CONCLUSIONS: Correlations were found between changes in UC disease activity and LRG, IL-6, pre-Alb, hs-CRP, CRP, and FC. LRG reflects disease activity during anti-TNF antibody therapy.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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Enthalten in: |
Journal of clinical medicine - 12(2023), 22 vom: 18. Nov. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Tatsumi, Yoshihiro [VerfasserIn] |
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Links: |
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Themen: |
Anti-TNF antibody therapy |
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Anmerkungen: |
Date Revised 27.11.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.3390/jcm12227165 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM364939958 |
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520 | |a BACKGROUND: In recent years, various biomarkers of ulcerative colitis (UC) have emerged; however, few studies have simultaneously examined the utility of multiple biomarkers for monitoring disease activity. Additionally, serum leucine-rich alpha-2 glycoprotein (LRG), a new biomarker, may show a blunt response to anti-TNF antibody therapy. This prospective study explored effective biomarkers that could monitor disease activity changes in patients with UC. In addition, we examined the effect of anti-TNF antibody therapy on changes in LRG | ||
520 | |a METHODS: Blood and stool samples were collected twice from patients with UC: at baseline and at least 8 weeks later. Changes in serum LRG, interleukin (IL)-6, prealbumin (pre-Alb), high-sensitivity C-reactive protein (hs-CRP), CRP, and fecal calprotectin (FC) were measured and correlated with changes in disease activity. The relationship between anti-TNF antibody therapy and LRG levels was also examined in patients with the same disease activity | ||
520 | |a RESULTS: Forty-eight patients with UC (96 samples) were analyzed. ΔLRG and ΔIL-6 correlated strongly with the change in the partial Mayo (pMayo) score between the two time points (ΔpMayo) (r = 0.686, 0.635, respectively). In contrast, FC and IL-6 were particularly accurate predictors of clinical remission, and their area under the curves (AUCs) were significantly higher than that of CRP (AUC: 0.81, 0.76 vs. 0.50; p = 0.001, 0.005). No association was found between the administration of anti-TNF antibody preparations and the LRG values | ||
520 | |a CONCLUSIONS: Correlations were found between changes in UC disease activity and LRG, IL-6, pre-Alb, hs-CRP, CRP, and FC. LRG reflects disease activity during anti-TNF antibody therapy | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a LRG (leucine-rich alpha-2-glycoprotein) | |
650 | 4 | |a anti-TNF antibody therapy | |
650 | 4 | |a biomarkers | |
650 | 4 | |a fecal calprotectin | |
650 | 4 | |a ulcerative colitis | |
700 | 1 | |a Kakimoto, Kazuki |e verfasserin |4 aut | |
700 | 1 | |a Hara, Azusa |e verfasserin |4 aut | |
700 | 1 | |a Mizuta, Noboru |e verfasserin |4 aut | |
700 | 1 | |a Numa, Keijiro |e verfasserin |4 aut | |
700 | 1 | |a Kinoshita, Naohiko |e verfasserin |4 aut | |
700 | 1 | |a Nakazawa, Kei |e verfasserin |4 aut | |
700 | 1 | |a Koshiba, Ryoji |e verfasserin |4 aut | |
700 | 1 | |a Hirata, Yuki |e verfasserin |4 aut | |
700 | 1 | |a Ota, Kazuhiro |e verfasserin |4 aut | |
700 | 1 | |a Miyazaki, Takako |e verfasserin |4 aut | |
700 | 1 | |a Nakamura, Shiro |e verfasserin |4 aut | |
700 | 1 | |a Sakagami, Kayoko |e verfasserin |4 aut | |
700 | 1 | |a Arimitsu, Shoko |e verfasserin |4 aut | |
700 | 1 | |a Ito, Hiroaki |e verfasserin |4 aut | |
700 | 1 | |a Nishikawa, Hiroki |e verfasserin |4 aut | |
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