Genomic alterations and diagnosis of renal cancer
© 2023. The Author(s)..
The application of molecular profiling has made substantial impact on the classification of urogenital tumors. Therefore, the 2022 World Health Organization incorporated the concept of molecularly defined renal tumor entities into its classification, including succinate dehydrogenase-deficient renal cell carcinoma (RCC), FH-deficient RCC, TFE3-rearranged RCC, TFEB-altered RCC, ALK-rearranged RCC, ELOC-mutated RCC, and renal medullary RCC, which are characterized by SMARCB1-deficiency. This review aims to provide an overview of the most important molecular alterations in renal cancer, with a specific focus on the diagnostic value of characteristic genomic aberrations, their chromosomal localization, and associations with renal tumor subtypes. It may not yet be the time to completely shift to a molecular RCC classification, but undoubtedly, the application of molecular profiling will enhance the accuracy of renal cancer diagnosis, and ultimately guide personalized treatment strategies for patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:484 |
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| Enthalten in: |
Virchows Archiv : an international journal of pathology - 484(2024), 2 vom: 23. Feb., Seite 323-337 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Xingming [VerfasserIn] |
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| Links: |
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| Themen: |
Diagnostic value |
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| Anmerkungen: |
Date Completed 19.03.2024 Date Revised 21.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00428-023-03700-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364909889 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a The application of molecular profiling has made substantial impact on the classification of urogenital tumors. Therefore, the 2022 World Health Organization incorporated the concept of molecularly defined renal tumor entities into its classification, including succinate dehydrogenase-deficient renal cell carcinoma (RCC), FH-deficient RCC, TFE3-rearranged RCC, TFEB-altered RCC, ALK-rearranged RCC, ELOC-mutated RCC, and renal medullary RCC, which are characterized by SMARCB1-deficiency. This review aims to provide an overview of the most important molecular alterations in renal cancer, with a specific focus on the diagnostic value of characteristic genomic aberrations, their chromosomal localization, and associations with renal tumor subtypes. It may not yet be the time to completely shift to a molecular RCC classification, but undoubtedly, the application of molecular profiling will enhance the accuracy of renal cancer diagnosis, and ultimately guide personalized treatment strategies for patients | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Diagnostic value | |
| 650 | 4 | |a Genomic alterations | |
| 650 | 4 | |a Kidney cancer | |
| 650 | 4 | |a Molecular defined entities | |
| 650 | 4 | |a Renal cell carcinoma | |
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| 700 | 1 | |a Rupp, Niels J |e verfasserin |4 aut | |
| 700 | 1 | |a Moch, Holger |e verfasserin |4 aut | |
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