Natural history of post-operative non-functioning pituitary adenomas - a single centre cohort analysis
PURPOSE: To study behaviour of endonasally operated non-functioning pituitary adenomas (NFPA) and propose a cost-effective stratified follow-up regimen.
METHODS: A single centre retrospective cohort analysis from June 2009 till December 2019. All endonasally operated pituitary adenomas were identified with sub-analysis of the NFPA's. Patients of all age groups with radiological follow-up more than 30 months were included. Patients with any kind of cranial intervention performed < within 30 months of surgery were excluded. The post-operative MRI for this cohort was evaluated until either any intervention was performed or until the last follow-up. The maximal tumour diameter in any plane (mm) was measured from the MRI scans. The annual growth rate and the statistical relationship between age, sex, IHC, Ki-67, resection %, residual tumour was calculated.
RESULTS: Out of 610 pituitary adenomas identified in the dataset, 116 patients met the inclusion criteria. Follow-up period ranged from 30 to 142 months (mean 78.5 months). A strong relationship existed between predicting tumour progression with first post-operative residue size (p = .001). A statistically significant relationship was found to be present between tumour growth and a residue of less than 10 mm diameter and 11-20 mm in diameter (Log rank p value .0216). On average, each patient with a residue < 5mm had MRI scans costing 976 £.
CONCLUSION: Based on statistical analysis and internal validation of the growth rate of the residue, we have proposed MRI follow-up scans. These recommendations have the potential to save more than 300 £per patient towards MRI costs and can lay down a marker for defining time interval of serial scans for post-operative NFPA's.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
British journal of neurosurgery - (2023) vom: 24. Nov., Seite 1-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shaikh, Salman T [VerfasserIn] |
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| Links: |
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| Themen: |
Growth rate |
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| Anmerkungen: |
Date Revised 24.11.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/02688697.2023.2284789 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364890649 |
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| 100 | 1 | |a Shaikh, Salman T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Natural history of post-operative non-functioning pituitary adenomas - a single centre cohort analysis |
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| 500 | |a Date Revised 24.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a PURPOSE: To study behaviour of endonasally operated non-functioning pituitary adenomas (NFPA) and propose a cost-effective stratified follow-up regimen | ||
| 520 | |a METHODS: A single centre retrospective cohort analysis from June 2009 till December 2019. All endonasally operated pituitary adenomas were identified with sub-analysis of the NFPA's. Patients of all age groups with radiological follow-up more than 30 months were included. Patients with any kind of cranial intervention performed < within 30 months of surgery were excluded. The post-operative MRI for this cohort was evaluated until either any intervention was performed or until the last follow-up. The maximal tumour diameter in any plane (mm) was measured from the MRI scans. The annual growth rate and the statistical relationship between age, sex, IHC, Ki-67, resection %, residual tumour was calculated | ||
| 520 | |a RESULTS: Out of 610 pituitary adenomas identified in the dataset, 116 patients met the inclusion criteria. Follow-up period ranged from 30 to 142 months (mean 78.5 months). A strong relationship existed between predicting tumour progression with first post-operative residue size (p = .001). A statistically significant relationship was found to be present between tumour growth and a residue of less than 10 mm diameter and 11-20 mm in diameter (Log rank p value .0216). On average, each patient with a residue < 5mm had MRI scans costing 976 £ | ||
| 520 | |a CONCLUSION: Based on statistical analysis and internal validation of the growth rate of the residue, we have proposed MRI follow-up scans. These recommendations have the potential to save more than 300 £per patient towards MRI costs and can lay down a marker for defining time interval of serial scans for post-operative NFPA's | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Growth rate | |
| 650 | 4 | |a non-functioning | |
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| 700 | 1 | |a Moughal, Saad |e verfasserin |4 aut | |
| 700 | 1 | |a Wael, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Nix, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Tyagi, Atul |e verfasserin |4 aut | |
| 700 | 1 | |a Phillips, Nick |e verfasserin |4 aut | |
| 700 | 1 | |a Sheikh, Asim |e verfasserin |4 aut | |
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