Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Alpha- and Delta-dominant circulation : I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021

IntroductionTwo large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021.AimWe aimed to measure VE against PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients ≥ 20 years, combining data from these networks during Alpha (March-June)- and Delta (June-December)-dominant periods, 2021.MethodsForty-six participating hospitals across 14 countries follow a similar generic protocol using the test-negative case-control design. We defined complete primary series vaccination (PSV) as two doses of a two-dose or one of a single-dose vaccine ≥ 14 days before onset.ResultsWe included 1,087 cases (538 controls) and 1,669 cases (1,442 controls) in the Alpha- and Delta-dominant periods, respectively. During the Alpha period, VE against hospitalisation with SARS-CoV2 for complete Comirnaty PSV was 85% (95% CI: 69-92) overall and 75% (95% CI: 42-90) in those aged ≥ 80 years. During the Delta period, among SARI patients ≥ 20 years with symptom onset ≥ 150 days from last PSV dose, VE for complete Comirnaty PSV was 54% (95% CI: 18-74). Among those receiving Comirnaty PSV and mRNA booster (any product) ≥ 150 days after last PSV dose, VE was 91% (95% CI: 57-98). In time-since-vaccination analysis, complete all-product PSV VE was > 90% in those with their last dose < 90 days before onset; ≥ 70% in those 90-179 days before onset.ConclusionsOur results from this EU multi-country hospital setting showed that VE for complete PSV alone was higher in the Alpha- than the Delta-dominant period, and addition of a first booster dose during the latter period increased VE to over 90%.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:28

Enthalten in:

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 28(2023), 47 vom: 23. Nov.

Sprache:

Englisch

Beteiligte Personen:

Rose, Angela Mc [VerfasserIn]
Nicolay, Nathalie [VerfasserIn]
Sandonis Martín, Virginia [VerfasserIn]
Mazagatos, Clara [VerfasserIn]
Petrović, Goranka [VerfasserIn]
Niessen, F Annabel [VerfasserIn]
Machado, Ausenda [VerfasserIn]
Launay, Odile [VerfasserIn]
Denayer, Sarah [VerfasserIn]
Seyler, Lucie [VerfasserIn]
Baruch, Joaquin [VerfasserIn]
Burgui, Cristina [VerfasserIn]
Loghin, Isabela I [VerfasserIn]
Domegan, Lisa [VerfasserIn]
Vaikutytė, Roberta [VerfasserIn]
Husa, Petr [VerfasserIn]
Panagiotakopoulos, George [VerfasserIn]
Aouali, Nassera [VerfasserIn]
Dürrwald, Ralf [VerfasserIn]
Howard, Jennifer [VerfasserIn]
Pozo, Francisco [VerfasserIn]
Sastre-Palou, Bartolomé [VerfasserIn]
Nonković, Diana [VerfasserIn]
Knol, Mirjam J [VerfasserIn]
Kislaya, Irina [VerfasserIn]
Luong Nguyen, Liem Binh [VerfasserIn]
Bossuyt, Nathalie [VerfasserIn]
Demuyser, Thomas [VerfasserIn]
Džiugytė, Aušra [VerfasserIn]
Martínez-Baz, Iván [VerfasserIn]
Popescu, Corneliu [VerfasserIn]
Duffy, Róisín [VerfasserIn]
Kuliešė, Monika [VerfasserIn]
Součková, Lenka [VerfasserIn]
Michelaki, Stella [VerfasserIn]
Simon, Marc [VerfasserIn]
Reiche, Janine [VerfasserIn]
Otero-Barrós, María Teresa [VerfasserIn]
Lovrić Makarić, Zvjezdana [VerfasserIn]
Bruijning-Verhagen, Patricia Cjl [VerfasserIn]
Gomez, Verónica [VerfasserIn]
Lesieur, Zineb [VerfasserIn]
Barbezange, Cyril [VerfasserIn]
Van Nedervelde, Els [VerfasserIn]
Borg, Maria-Louise [VerfasserIn]
Castilla, Jesús [VerfasserIn]
Lazar, Mihaela [VerfasserIn]
O'Donnell, Joan [VerfasserIn]
Jonikaitė, Indrė [VerfasserIn]
Demlová, Regina [VerfasserIn]
Amerali, Marina [VerfasserIn]
Wirtz, Gil [VerfasserIn]
Tolksdorf, Kristin [VerfasserIn]
Valenciano, Marta [VerfasserIn]
Bacci, Sabrina [VerfasserIn]
Kissling, Esther [VerfasserIn]
I-MOVE-COVID-19 hospital study team [VerfasserIn]
VEBIS hospital study team [VerfasserIn]
Members of the I-MOVE-COVID-19 and VEBIS hospital study teams (in addition to the named authors) [VerfasserIn]
Karabuva, Svjetlana [Sonstige Person]
Petrić, Petra Tomaš [Sonstige Person]
Marković, Marija [Sonstige Person]
Ljubičić, Sandra [Sonstige Person]
Mahmutović, Bojana [Sonstige Person]
Tabain, Irena [Sonstige Person]
Smoljo, Petra [Sonstige Person]
Novosel, Iva Pem [Sonstige Person]
Melillo, Tanya [Sonstige Person]
Cauchi, John Paul [Sonstige Person]
Lissoir, Benédicte [Sonstige Person]
Holemans, Xavier [Sonstige Person]
Hainaut, Marc [Sonstige Person]
Dauby, Nicolas [Sonstige Person]
Delaere, Benedicte [Sonstige Person]
Bourgeois, Marc [Sonstige Person]
Petit, Evelyn [Sonstige Person]
Reynders, Marijke [Sonstige Person]
Jouck, Door [Sonstige Person]
Magerman, Koen [Sonstige Person]
Bleyen, Marieke [Sonstige Person]
Vermeulen, Melissa [Sonstige Person]
Fierens, Sébastien [Sonstige Person]
Dufrasne, François [Sonstige Person]
Daelemans, Siel [Sonstige Person]
Al Kerwi, Ala'a [Sonstige Person]
Berthet, Francoise [Sonstige Person]
Fagherazzi, Guy [Sonstige Person]
Alexandre, Myriam [Sonstige Person]
Bennett, Charlene [Sonstige Person]
Christle, Jim [Sonstige Person]
Connell, Jeff [Sonstige Person]
Doran, Peter [Sonstige Person]
Feeney, Laura [Sonstige Person]
Maharjan, Binita [Sonstige Person]
McDermott, Sinead [Sonstige Person]
McNamara, Rosa [Sonstige Person]
Nurdin, Nadra [Sonstige Person]
Cissé, Salif Mamadou [Sonstige Person]
L'Honneur, Anne-Sophie [Sonstige Person]
Duval, Xavier [Sonstige Person]
Costa, Yolande [Sonstige Person]
Nadhira, Fidouh [Sonstige Person]
Galtier, Florence [Sonstige Person]
Crantelle, Laura [Sonstige Person]
Foulongne, Vincent [Sonstige Person]
Vanhems, Phillipe [Sonstige Person]
Amour, Sélilah [Sonstige Person]
Lina, Bruno [Sonstige Person]
Lainé, Fabrice [Sonstige Person]
Gallais, Laetitia [Sonstige Person]
Lagathu, Gisèle [Sonstige Person]
Maisa, Anna [Sonstige Person]
Saidi, Yacine [Sonstige Person]
Durier, Christine [Sonstige Person]
Bauer, Rebecca [Sonstige Person]
Rodrigues, Ana Paula [Sonstige Person]
Silva, Adriana [Sonstige Person]
Guiomar, Raquel [Sonstige Person]
Tavares, Margarida [Sonstige Person]
Pereira, Débora [Sonstige Person]
Manata, Maria José [Sonstige Person]
Gruner, Heidi [Sonstige Person]
Almeida, André [Sonstige Person]
Pinto, Paula [Sonstige Person]
Bárbara, Cristina [Sonstige Person]
Casado, Itziar [Sonstige Person]
Miqueleiz, Ana [Sonstige Person]
Navascués, Ana [Sonstige Person]
Trobajo-Sanmartín, Camino [Sonstige Person]
Fernández-Huerta, Miguel [Sonstige Person]
Portillo, María Eugenia [Sonstige Person]
Ezpeleta, Carmen [Sonstige Person]
Egüés, Nerea [Sonstige Person]
Cenoz, Manuel García [Sonstige Person]
Ardanaz, Eva [Sonstige Person]
Guevara, Marcela [Sonstige Person]
Moreno-Iribas, Conchi [Sonstige Person]
Orlíková, Hana [Sonstige Person]
Dorobat, Carmen Mihaela [Sonstige Person]
Manciuc, Carmen [Sonstige Person]
Florescu, Simin Aysel [Sonstige Person]
Marin, Alexandru [Sonstige Person]
Dinu, Sorin [Sonstige Person]
Pascu, Catalina [Sonstige Person]
Ivanciuc, Alina [Sonstige Person]
Bistriceanu, Iulia [Sonstige Person]
Oprea, Mihaela [Sonstige Person]
Mihai, Maria Elena [Sonstige Person]
Buda, Silke [Sonstige Person]
Preuss, Ute [Sonstige Person]
Wedde, Marianne [Sonstige Person]
Mickienė, Auksė [Sonstige Person]
Gefenaitė, Giedrė [Sonstige Person]
Moren, Alain [Sonstige Person]
Nardone, Anthony [Sonstige Person]

Links:

Volltext

Themen:

Alpha
BNT162 Vaccine
Delta
Europe
Hospital
Journal Article
RNA, Viral
SARS-CoV-2
Vaccine effectiveness

Anmerkungen:

Date Completed 27.11.2023

Date Revised 12.01.2024

published: Print

Citation Status MEDLINE

doi:

10.2807/1560-7917.ES.2023.28.47.2300186

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM364889217