Mn(II) Optimized Sono/Chemodynamic Effect of Porphyrin-Metal-Organic Framework Nanosheets for MRI-Guided Colon Cancer Therapy and Metastasis Suppression
© 2023 Wiley‐VCH GmbH..
Sonodynamic therapy (SDT) offers a remarkable non-invasive ultrasound (US) treatment by activating sonosensitizer and generating reactive oxygen species (ROS) to inhibit tumor growth. The development of multifunctional, biocompatible, and highly effective sonosensitizers remains a current priority for SDT. Herein, the first report that Mn(II) ions chelated Gd-TCPP (GMT) nanosheets (NSs) are synthesized via a simple reflux method and encapsulated with pluronic F-127 to form novel sonosensitizers (GMTF). The GMTF NSs produce a high yield of ROS under US irradiation due to the decreased highest occupied molecular orbital-lowest unoccupied molecular orbital gap energy (2.7-1.28 eV). Moreover, Mn(II) ions endow GMTF with a fascinating Fenton-like activity to produce hydroxyl radicals in support of chemodynamic therapy (CDT). It is also effectively used in magnetic resonance imaging (MRI) with high relaxation rate (r 1: 4.401 mM-1 s-1) to track the accumulation of NSs in tumors. In vivo results indicate that the SDT and CDT in combination with programmed cell death protein 1 antibody (anti-PD-1) show effective metastasis prevention effects, and 70% of the mice in the GMTF + US + anti-PD-1 group survived for 60 days. In conclusion, this study develops a sonosensitizer with promising potential for utilizing both MRI-guided SDT and CDT strategies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Small (Weinheim an der Bergstrasse, Germany) - 20(2024), 15 vom: 28. Apr., Seite e2306364 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hang, Lifeng [VerfasserIn] |
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| Links: |
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| Themen: |
Chemodynamic therapy |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 15.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/smll.202306364 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364884592 |
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| 520 | |a Sonodynamic therapy (SDT) offers a remarkable non-invasive ultrasound (US) treatment by activating sonosensitizer and generating reactive oxygen species (ROS) to inhibit tumor growth. The development of multifunctional, biocompatible, and highly effective sonosensitizers remains a current priority for SDT. Herein, the first report that Mn(II) ions chelated Gd-TCPP (GMT) nanosheets (NSs) are synthesized via a simple reflux method and encapsulated with pluronic F-127 to form novel sonosensitizers (GMTF). The GMTF NSs produce a high yield of ROS under US irradiation due to the decreased highest occupied molecular orbital-lowest unoccupied molecular orbital gap energy (2.7-1.28 eV). Moreover, Mn(II) ions endow GMTF with a fascinating Fenton-like activity to produce hydroxyl radicals in support of chemodynamic therapy (CDT). It is also effectively used in magnetic resonance imaging (MRI) with high relaxation rate (r 1: 4.401 mM-1 s-1) to track the accumulation of NSs in tumors. In vivo results indicate that the SDT and CDT in combination with programmed cell death protein 1 antibody (anti-PD-1) show effective metastasis prevention effects, and 70% of the mice in the GMTF + US + anti-PD-1 group survived for 60 days. In conclusion, this study develops a sonosensitizer with promising potential for utilizing both MRI-guided SDT and CDT strategies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a chemodynamic therapy | |
| 650 | 4 | |a colon cancer | |
| 650 | 4 | |a magnetic resonance imaging | |
| 650 | 4 | |a metastasis suppression | |
| 650 | 4 | |a sonodynamic therapy | |
| 650 | 7 | |a Metal-Organic Frameworks |2 NLM | |
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| 700 | 1 | |a Li, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wuming |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Laiping |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Chunze |e verfasserin |4 aut | |
| 700 | 1 | |a Qu, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Lianyi |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Guihua |e verfasserin |4 aut | |
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