Conductive 3D Ti3C2Tx MXene-Matrigel hydrogels promote proliferation and neuronal differentiation of neural stem cells
Copyright © 2023. Published by Elsevier B.V..
Neural stem cells (NSCs) transplantation has great potential in the field of central nervous system injury repair, but the limited differentiation efficiency of transplanted NSCs often affects the therapeutic effect. In this paper, we present a stable three-dimensional (3D) conductive hydrogel prepared by cross-linking MXenes to Matrigel hydrogel. Benefiting from 3D microporous network structure of hydrogel, the conductive hydrogel can provide an extracellular matrix-like substrate for NSCs growth. Moreover, with the addition of Ti3C2Tx MXenes, the composite has excellent electrical conductivity and biocompatibility. It is demonstrated that MXene-Matrigel hydrogels can effectively promote the proliferation and differentiation of NSCs. These findings provide experimental evidence for understanding the regulatory role of conductive hydrogels on NSCs and provides new strategies for neural tissue engineering.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:233 |
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| Enthalten in: |
Colloids and surfaces. B, Biointerfaces - 233(2023) vom: 28. Jan., Seite 113652 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wei, Hao [VerfasserIn] |
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| Links: |
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| Themen: |
119978-18-6 |
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| Anmerkungen: |
Date Completed 07.12.2023 Date Revised 07.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.colsurfb.2023.113652 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364801077 |
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| 520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
| 520 | |a Neural stem cells (NSCs) transplantation has great potential in the field of central nervous system injury repair, but the limited differentiation efficiency of transplanted NSCs often affects the therapeutic effect. In this paper, we present a stable three-dimensional (3D) conductive hydrogel prepared by cross-linking MXenes to Matrigel hydrogel. Benefiting from 3D microporous network structure of hydrogel, the conductive hydrogel can provide an extracellular matrix-like substrate for NSCs growth. Moreover, with the addition of Ti3C2Tx MXenes, the composite has excellent electrical conductivity and biocompatibility. It is demonstrated that MXene-Matrigel hydrogels can effectively promote the proliferation and differentiation of NSCs. These findings provide experimental evidence for understanding the regulatory role of conductive hydrogels on NSCs and provides new strategies for neural tissue engineering | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Conductive biomaterial | |
| 650 | 4 | |a Extracellular matrix | |
| 650 | 4 | |a Matrigel hydrogels | |
| 650 | 4 | |a Neural stem cell | |
| 650 | 4 | |a Ti(3)C(2)T(x) MXenes | |
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| 700 | 1 | |a Gu, Yajun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ao |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Panpan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dingding |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Feihu |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Xiaofeng |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Xiaoyun |e verfasserin |4 aut | |
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