Illuminating Airway Nerve Structure and Function in Chronic Cough
© 2023. The Author(s)..
Airway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulation of airway nerves underlies the development and manifestations of airway diseases such as chronic cough, where sensitization of neural pathways leads to excessive cough triggering. Nerves are heterogeneous in both expression and function. Recent advances in confocal imaging and in targeted genetic manipulation of airway nerves have expanded our ability to visualize neural organization, study neuro-immune interactions, and selectively modulate nerve activation. As a result, we have an unprecedented ability to quantitatively assess neural remodeling and its role in the development of airway disease. This review highlights our existing understanding of neural heterogeneity and how advances in methodology have illuminated airway nerve morphology and function in health and disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:201 |
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| Enthalten in: |
Lung - 201(2023), 6 vom: 20. Dez., Seite 499-509 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kornfield, James [VerfasserIn] |
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| Links: |
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| Themen: |
Asthma |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 12.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00408-023-00659-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364769041 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Airway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulation of airway nerves underlies the development and manifestations of airway diseases such as chronic cough, where sensitization of neural pathways leads to excessive cough triggering. Nerves are heterogeneous in both expression and function. Recent advances in confocal imaging and in targeted genetic manipulation of airway nerves have expanded our ability to visualize neural organization, study neuro-immune interactions, and selectively modulate nerve activation. As a result, we have an unprecedented ability to quantitatively assess neural remodeling and its role in the development of airway disease. This review highlights our existing understanding of neural heterogeneity and how advances in methodology have illuminated airway nerve morphology and function in health and disease | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Parasympathetic nerve | |
| 650 | 4 | |a Sensory nerve | |
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| 700 | 1 | |a Mize, Emily |e verfasserin |4 aut | |
| 700 | 1 | |a Drake, Matthew G |e verfasserin |4 aut | |
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