Sieving out non-celiac gluten sensitivity amongst patients with irritable bowel syndrome
Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved..
OBJECTIVES: It is challenging to make diagnosis of non-celiac gluten sensitivity/non-celiac wheat sensitivity (NCGS/NCWS) in clinical practice, since there is no biomarker and diagnosis is based on response to gluten-free-diet (GFD). We used anti-gliadin antibody (AGA) for screening patients with IBS for gluten-sensitivity.
METHODS: 492 Adult-patients with IBS underwent screening for celiac disease and gluten-sensitivity using IgA anti-tissue transglutaminase antibody and IgA-AGA and IgG-AGA, respectively. Patients with positive AGA (IgA and/or IgG) were invited to follow GFD, those willing were put on GFD for 6-weeks. Responsive patients were given gluten re-challenge. Diagnosis of NCGS was confirmed if they had recurrence of symptoms.
RESULTS: Of 492 patients with IBS, AGA was positive in 61(12.4 %), hence suspected to have gluten-sensitivity. Of 31 who agreed to participate and followed GFD for 6-weeks, 17 (54.8 %) had complete (>30 % improvement) and 10(32.2 %) had partial (>20 % improvement) response. All 17 complete-responders were given gluten re-challenge for 6-weeks, symptoms recurred in all and hence were confirmed to have NCGS/NCWS. Significant decrease in AGA levels occurred almost in all GFD-responders.
CONCLUSIONS: 12.4 % IBS patients have biological evidence of gluten/wheat-sensitivity. Almost 87 % patients with IBS having AGA responded to GFD. The value of AGA may further be explored as a biomarker for screening for the presence of NCGS, before recommending this test for the clinical practice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 56(2024), 3 vom: 16. Feb., Seite 451-457 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ahmed, Anam [VerfasserIn] |
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| Links: |
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| Themen: |
8002-80-0 |
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| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 19.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.dld.2023.10.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36476645X |
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| 100 | 1 | |a Ahmed, Anam |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sieving out non-celiac gluten sensitivity amongst patients with irritable bowel syndrome |
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| 500 | |a Date Completed 19.02.2024 | ||
| 500 | |a Date Revised 19.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: It is challenging to make diagnosis of non-celiac gluten sensitivity/non-celiac wheat sensitivity (NCGS/NCWS) in clinical practice, since there is no biomarker and diagnosis is based on response to gluten-free-diet (GFD). We used anti-gliadin antibody (AGA) for screening patients with IBS for gluten-sensitivity | ||
| 520 | |a METHODS: 492 Adult-patients with IBS underwent screening for celiac disease and gluten-sensitivity using IgA anti-tissue transglutaminase antibody and IgA-AGA and IgG-AGA, respectively. Patients with positive AGA (IgA and/or IgG) were invited to follow GFD, those willing were put on GFD for 6-weeks. Responsive patients were given gluten re-challenge. Diagnosis of NCGS was confirmed if they had recurrence of symptoms | ||
| 520 | |a RESULTS: Of 492 patients with IBS, AGA was positive in 61(12.4 %), hence suspected to have gluten-sensitivity. Of 31 who agreed to participate and followed GFD for 6-weeks, 17 (54.8 %) had complete (>30 % improvement) and 10(32.2 %) had partial (>20 % improvement) response. All 17 complete-responders were given gluten re-challenge for 6-weeks, symptoms recurred in all and hence were confirmed to have NCGS/NCWS. Significant decrease in AGA levels occurred almost in all GFD-responders | ||
| 520 | |a CONCLUSIONS: 12.4 % IBS patients have biological evidence of gluten/wheat-sensitivity. Almost 87 % patients with IBS having AGA responded to GFD. The value of AGA may further be explored as a biomarker for screening for the presence of NCGS, before recommending this test for the clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-gliadin antibody | |
| 650 | 4 | |a Celiac disease | |
| 650 | 4 | |a Gluten sensitivity | |
| 650 | 4 | |a Non-celiac wheat sensitivity | |
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| 650 | 7 | |a Immunoglobulin A |2 NLM | |
| 700 | 1 | |a Dixit, Kunal |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Alka |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Ashish |e verfasserin |4 aut | |
| 700 | 1 | |a Mehtab, Wajiha |e verfasserin |4 aut | |
| 700 | 1 | |a Prasad, Shubham |e verfasserin |4 aut | |
| 700 | 1 | |a Rajput, Mahendra Singh |e verfasserin |4 aut | |
| 700 | 1 | |a Chauhan, Ashish |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Ankit |e verfasserin |4 aut | |
| 700 | 1 | |a Mehta, Shubham |e verfasserin |4 aut | |
| 700 | 1 | |a Ahuja, Vineet |e verfasserin |4 aut | |
| 700 | 1 | |a Shouche, Yogesh |e verfasserin |4 aut | |
| 700 | 1 | |a Dhotre, Dhiraj |e verfasserin |4 aut | |
| 700 | 1 | |a Makharia, Govind K |e verfasserin |4 aut | |
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