Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
BACKGROUND: We determined the effects and an accurate marker of periodontal treatment on serum interleukin (IL)-6 and high-sensitivity C-reactive protein (HsCRP) levels in systemically healthy individuals with periodontal disease.
METHODS: This multicenter study included systemically healthy individuals with periodontal disease who received initial periodontal treatment and had no periodontal treatment history. Periodontal parameters, including periodontal inflamed surface area, masticatory efficiency, and periodontal disease classification; serum IL-6 and HsCRP levels; and serum immunoglobulin (Ig)G titers against periodontal pathogens were evaluated at baseline and after treatment. Subjects were classified as low or high responders (group) based on periodontal inflamed surface area changes.
RESULTS: There were 153 participants. Only periodontal inflamed surface area changes were markedly different between low and high responders. Periodontal treatment (time point) decreased both serum IL-6 and HsCRP levels. The interaction between group and time point was remarkable only for serum IL-6 levels. Changes in serum immunoglobulin (Ig)G titers against periodontal pathogens were not associated with IL-6 changes in high responders. We analyzed the indirect effect of serum anti-Porphyromonas gingivalis type 2 IgG titer changes using mediation analysis and found no significance. However, the direct effect of group (low or high responder) on IL-6 changes was considerable.
CONCLUSIONS: Periodontal treatment effectively decreased serum IL-6 levels, independent of periodontal pathogen infection, in systemically healthy individuals with periodontal disease.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:137 |
---|---|
Enthalten in: |
The American journal of medicine - 137(2024), 3 vom: 28. Feb., Seite 273-279.e2 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Matsuda, Shinji [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 27.02.2024 Date Revised 27.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.amjmed.2023.11.001 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364761679 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM364761679 | ||
003 | DE-627 | ||
005 | 20240229163756.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.amjmed.2023.11.001 |2 doi | |
028 | 5 | 2 | |a pubmed24n1308.xml |
035 | |a (DE-627)NLM364761679 | ||
035 | |a (NLM)37984772 | ||
035 | |a (PII)S0002-9343(23)00706-4 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Matsuda, Shinji |e verfasserin |4 aut | |
245 | 1 | 0 | |a Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.02.2024 | ||
500 | |a Date Revised 27.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
520 | |a BACKGROUND: We determined the effects and an accurate marker of periodontal treatment on serum interleukin (IL)-6 and high-sensitivity C-reactive protein (HsCRP) levels in systemically healthy individuals with periodontal disease | ||
520 | |a METHODS: This multicenter study included systemically healthy individuals with periodontal disease who received initial periodontal treatment and had no periodontal treatment history. Periodontal parameters, including periodontal inflamed surface area, masticatory efficiency, and periodontal disease classification; serum IL-6 and HsCRP levels; and serum immunoglobulin (Ig)G titers against periodontal pathogens were evaluated at baseline and after treatment. Subjects were classified as low or high responders (group) based on periodontal inflamed surface area changes | ||
520 | |a RESULTS: There were 153 participants. Only periodontal inflamed surface area changes were markedly different between low and high responders. Periodontal treatment (time point) decreased both serum IL-6 and HsCRP levels. The interaction between group and time point was remarkable only for serum IL-6 levels. Changes in serum immunoglobulin (Ig)G titers against periodontal pathogens were not associated with IL-6 changes in high responders. We analyzed the indirect effect of serum anti-Porphyromonas gingivalis type 2 IgG titer changes using mediation analysis and found no significance. However, the direct effect of group (low or high responder) on IL-6 changes was considerable | ||
520 | |a CONCLUSIONS: Periodontal treatment effectively decreased serum IL-6 levels, independent of periodontal pathogen infection, in systemically healthy individuals with periodontal disease | ||
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Chronic inflammation | |
650 | 4 | |a HsCRP | |
650 | 4 | |a Periodontal inflamed surface area | |
650 | 4 | |a Periodontal pathogens | |
650 | 4 | |a Serum IL-6 | |
650 | 4 | |a Systemically healthy patients with periodontal disease | |
650 | 7 | |a C-Reactive Protein |2 NLM | |
650 | 7 | |a 9007-41-4 |2 NLM | |
650 | 7 | |a Interleukin-6 |2 NLM | |
650 | 7 | |a Immunoglobulins |2 NLM | |
700 | 1 | |a Shintani, Tomoaki |e verfasserin |4 aut | |
700 | 1 | |a Miyagawa, Tsuyoshi |e verfasserin |4 aut | |
700 | 1 | |a Yumoto, Hiromichi |e verfasserin |4 aut | |
700 | 1 | |a Komatsu, Yasutaka |e verfasserin |4 aut | |
700 | 1 | |a Dewake, Nanae |e verfasserin |4 aut | |
700 | 1 | |a Iwata, Takanori |e verfasserin |4 aut | |
700 | 1 | |a Nagano, Takatoshi |e verfasserin |4 aut | |
700 | 1 | |a Morozumi, Toshiya |e verfasserin |4 aut | |
700 | 1 | |a Goto, Ryoma |e verfasserin |4 aut | |
700 | 1 | |a Kato, Satsuki |e verfasserin |4 aut | |
700 | 1 | |a Kitamura, Masahiro |e verfasserin |4 aut | |
700 | 1 | |a Shin, Kitetsu |e verfasserin |4 aut | |
700 | 1 | |a Sekino, Satoshi |e verfasserin |4 aut | |
700 | 1 | |a Yamashita, Akiko |e verfasserin |4 aut | |
700 | 1 | |a Yamashita, Keiko |e verfasserin |4 aut | |
700 | 1 | |a Yoshimura, Atsutoshi |e verfasserin |4 aut | |
700 | 1 | |a Sugaya, Tsutomu |e verfasserin |4 aut | |
700 | 1 | |a Takashiba, Shogo |e verfasserin |4 aut | |
700 | 1 | |a Taguchi, Yoichiro |e verfasserin |4 aut | |
700 | 1 | |a Nemoto, Eiji |e verfasserin |4 aut | |
700 | 1 | |a Nishi, Hiromi |e verfasserin |4 aut | |
700 | 1 | |a Mizuno, Noriyoshi |e verfasserin |4 aut | |
700 | 1 | |a Numabe, Yukihiro |e verfasserin |4 aut | |
700 | 1 | |a Kawaguchi, Hiroyuki |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The American journal of medicine |d 1946 |g 137(2024), 3 vom: 28. Feb., Seite 273-279.e2 |w (DE-627)NLM000114472 |x 1555-7162 |7 nnns |
773 | 1 | 8 | |g volume:137 |g year:2024 |g number:3 |g day:28 |g month:02 |g pages:273-279.e2 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.amjmed.2023.11.001 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 137 |j 2024 |e 3 |b 28 |c 02 |h 273-279.e2 |