Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling : relevance to aggressive behavior in humans
© 2023. The Author(s)..
Oxytocin is a neuropeptide produced mainly in the hypothalamus and secreted in the CNS and blood. In the brain, it plays a major role in promoting social interactions. Here we show that in human plasma about 60% of oxytocin is naturally bound to IgG which modulates oxytocin receptor signaling. Further, we found that IgG of violent aggressive inmates were characterized by lower affinity for oxytocin, causing decreased oxytocin carrier capacity and reduced receptor activation as compared to men from the general population. Moreover, peripheral administration of oxytocin together with human oxytocin-reactive IgG to resident mice in a resident-intruder test, reduced c-fos activation in several brain regions involved in the regulation of aggressive/defensive behavior correlating with the attack number and duration. We conclude that IgG is a natural oxytocin carrier protein modulating oxytocin receptor signaling which can be relevant to the biological mechanisms of aggressive behavior.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
Discover mental health - 3(2023), 1 vom: 19. Okt., Seite 21 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Værøy, Henning [VerfasserIn] |
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| Links: |
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| Themen: |
Aggressive behavior |
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| Anmerkungen: |
Date Revised 23.11.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s44192-023-00048-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364745274 |
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| 520 | |a Oxytocin is a neuropeptide produced mainly in the hypothalamus and secreted in the CNS and blood. In the brain, it plays a major role in promoting social interactions. Here we show that in human plasma about 60% of oxytocin is naturally bound to IgG which modulates oxytocin receptor signaling. Further, we found that IgG of violent aggressive inmates were characterized by lower affinity for oxytocin, causing decreased oxytocin carrier capacity and reduced receptor activation as compared to men from the general population. Moreover, peripheral administration of oxytocin together with human oxytocin-reactive IgG to resident mice in a resident-intruder test, reduced c-fos activation in several brain regions involved in the regulation of aggressive/defensive behavior correlating with the attack number and duration. We conclude that IgG is a natural oxytocin carrier protein modulating oxytocin receptor signaling which can be relevant to the biological mechanisms of aggressive behavior | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aggressive behavior | |
| 650 | 4 | |a Autoantibodies | |
| 650 | 4 | |a Brain | |
| 650 | 4 | |a Human | |
| 650 | 4 | |a Intracellular signaling | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Neuroendocrinology | |
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| 650 | 4 | |a Oxytocin | |
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| 650 | 4 | |a c-fos | |
| 700 | 1 | |a Lahaye, Emilie |e verfasserin |4 aut | |
| 700 | 1 | |a Dubessy, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Benard, Magalie |e verfasserin |4 aut | |
| 700 | 1 | |a Nicol, Marion |e verfasserin |4 aut | |
| 700 | 1 | |a Cherifi, Yamina |e verfasserin |4 aut | |
| 700 | 1 | |a Takhlidjt, Saloua |e verfasserin |4 aut | |
| 700 | 1 | |a do Rego, Jean-Luc |e verfasserin |4 aut | |
| 700 | 1 | |a do Rego, Jean-Claude |e verfasserin |4 aut | |
| 700 | 1 | |a Chartrel, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Fetissov, Sergueï O |e verfasserin |4 aut | |
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