Promotion of a quality standard for Paris polyphylla var. yunnanensis based on the efficacy-oriented effect-constituent index
Copyright © 2023 Elsevier B.V. All rights reserved..
Multi-component determination and bioassays used for the quality control of traditional Chinese medicine (TCM) may have certain shortcomings. The effect-constituent index (ECI) is a quality evaluation index weighted by chemical composition analysis and effect detection. This index can be established by the dose-effect relationship of the active ingredients in TCM. In this study, Paris polyphylla var. yunnanensis (PY) was selected as the representative drug. Chemical evaluation and bioactivity evaluation were combined to establish the ECI, to compensate for the deficiency of a single evaluation method to some extent, and can be related to the efficacy of PY, in order to improve its quality standard. The ECI not only reflects the contribution of component content to the quality of PY, but also relates to clinical efficacy and reflects the influence of different components on the biological activity. Moreover, this study provided a reference method for the quality control of other TCMs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:238 |
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| Enthalten in: |
Journal of pharmaceutical and biomedical analysis - 238(2023) vom: 20. Jan., Seite 115843 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Yang [VerfasserIn] |
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| Links: |
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| Themen: |
Bioactivity evaluation |
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| Anmerkungen: |
Date Completed 06.12.2023 Date Revised 06.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jpba.2023.115843 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364723947 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Multi-component determination and bioassays used for the quality control of traditional Chinese medicine (TCM) may have certain shortcomings. The effect-constituent index (ECI) is a quality evaluation index weighted by chemical composition analysis and effect detection. This index can be established by the dose-effect relationship of the active ingredients in TCM. In this study, Paris polyphylla var. yunnanensis (PY) was selected as the representative drug. Chemical evaluation and bioactivity evaluation were combined to establish the ECI, to compensate for the deficiency of a single evaluation method to some extent, and can be related to the efficacy of PY, in order to improve its quality standard. The ECI not only reflects the contribution of component content to the quality of PY, but also relates to clinical efficacy and reflects the influence of different components on the biological activity. Moreover, this study provided a reference method for the quality control of other TCMs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bioactivity evaluation | |
| 650 | 4 | |a Chemical evaluation | |
| 650 | 4 | |a Effect-constituent index | |
| 650 | 4 | |a HepG2 cell | |
| 650 | 4 | |a Paris polyphylla var. yunnanensis | |
| 700 | 1 | |a Wang, Le |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Wanqing |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Qiufeng |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Huimei |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Rouyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Hanzhu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Haizhu |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Conglong |e verfasserin |4 aut | |
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