Cationic fructan-based pH and intestinal flora dual stimulation nanoparticle with berberine for targeted therapy of IBD
Copyright © 2023 Elsevier B.V. All rights reserved..
Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a mixed fructan based nanoparticle with dual targeted stimulation of pH and intestinal flora to effectively deliver berberine for the treatment of ulcerative colitis (UC). The complex of fructan based nanoparticle and berberine (BBRNPs) significantly ameliorated the inflammatory response of sodium dextran sulfate (DSS)-induced colitis in mice by inhibiting the activation of NF-κB/STAT-3 pathway and increasing tight junction protein expression in vivo. Importantly, BBRNPs improved the responsiveness of colitis microbiome and effectively regulated the relative homeostasis of harmful flora Enterobacteriaceae and Escherichia-shigolla, and beneficial flora Ruminococcaceae and Akkermansiaceae. This study provides a promising strategy for the effective treatment of UC and expands the application of branched fructan in pharmaceutics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:256 |
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| Enthalten in: |
International journal of biological macromolecules - 256(2024), Pt 2 vom: 20. Jan., Seite 127987 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Hongyu [VerfasserIn] |
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| Links: |
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| Themen: |
0I8Y3P32UF |
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| Anmerkungen: |
Date Completed 18.01.2024 Date Revised 18.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijbiomac.2023.127987 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a mixed fructan based nanoparticle with dual targeted stimulation of pH and intestinal flora to effectively deliver berberine for the treatment of ulcerative colitis (UC). The complex of fructan based nanoparticle and berberine (BBRNPs) significantly ameliorated the inflammatory response of sodium dextran sulfate (DSS)-induced colitis in mice by inhibiting the activation of NF-κB/STAT-3 pathway and increasing tight junction protein expression in vivo. Importantly, BBRNPs improved the responsiveness of colitis microbiome and effectively regulated the relative homeostasis of harmful flora Enterobacteriaceae and Escherichia-shigolla, and beneficial flora Ruminococcaceae and Akkermansiaceae. This study provides a promising strategy for the effective treatment of UC and expands the application of branched fructan in pharmaceutics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Berberine | |
| 650 | 4 | |a Fructan | |
| 650 | 4 | |a Nanoparticles | |
| 650 | 4 | |a Ulcerative colitis | |
| 650 | 4 | |a pH and intestinal flora dual response | |
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| 700 | 1 | |a Yang, Wenna |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xiongzhi |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Luyao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Weimei |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Hongyue |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Luqi |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Lanping |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Wenyuan |e verfasserin |4 aut | |
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