Association of known SARS-CoV-2 serostatus and adherence to personal protection measures and the impact of personal protective measures on seropositivity in a population-based cross-sectional study (MuSPAD) in Germany
© 2023. The Author(s)..
BACKGROUND: In 2020/2021 in Germany, several non-pharmacological interventions were introduced to lower the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated to what extent knowledge of prior infection with SARS-CoV-2 or vaccination status influenced the use of personal protection measures (PPM). Further, we were interested in the effect of compliance with PPM on SARS-CoV-2 serostatus.
METHODS: Data was based on a sequential, multilocal seroprevalence study (MuSPAD), carried out in eight locations from July 2020 to August 2021. We estimated the association between a known SARS-CoV-2 serostatus (reported positive PCR test or vaccination) and self-reported PPM behavior (hand hygiene, physical distancing, wearing face mask), just as the association of PPM compliance with seropositivity against nucleocapsid (NC), receptor-binding domain (RBD), and spike protein (S) antigens. We identified relevant variables and deduced adjustment sets with directed acyclic graphs (DAG), and applied mixed logistic regression.
RESULTS: Out of the 22,297 participants (median age: 54 years, 43% male), 781 were classified as SARS-CoV-2-infected and 3,877 had a vaccinated immune response. Vaccinated individuals were less likely to keep 1.5 m distance [OR = 0.74 (95% CI: 0.57-0.97)] and only partly physically distanced [OR = 0.71 (95% CI: 0.58-0.87)]. Participants with self-reported positive PCR test had a lower chance of adhering partly to physical distancing [OR = 0.70 (95% CI: 0.50-0.99)] in comparison to the reference group. Higher odds of additionally wearing a face mask was observed in vaccinated [OR = 1.28 (95% CI: 1.08-1.51)] even if it was not obligatory. Overall, among unvaccinated participants, we found little evidence of lower odds of seropositivity given mask wearing [OR: 0.91 (95% CI: 0.71-1.16)], physical distancing [OR: 0.84 (95% CI: 0.59-1.20)] and no evidence for completely adhering to hand cleaning [OR: 0.97 (95% CI: 0.29-3.22)].
CONCLUSIONS: A known confirmed prior infection and vaccination may have the potential to influence adherence to PPM.
| Errataetall: |
ErratumIn: BMC Public Health. 2024 Feb 23;24(1):593. - PMID 38395912 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
BMC public health - 23(2023), 1 vom: 17. Nov., Seite 2281 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kettlitz, R [VerfasserIn] |
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| Links: |
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| Themen: |
Germany |
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| Anmerkungen: |
Date Completed 20.11.2023 Date Revised 23.02.2024 published: Electronic ErratumIn: BMC Public Health. 2024 Feb 23;24(1):593. - PMID 38395912 Citation Status MEDLINE |
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| doi: |
10.1186/s12889-023-17121-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Association of known SARS-CoV-2 serostatus and adherence to personal protection measures and the impact of personal protective measures on seropositivity in a population-based cross-sectional study (MuSPAD) in Germany |
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| 500 | |a Date Revised 23.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a ErratumIn: BMC Public Health. 2024 Feb 23;24(1):593. - PMID 38395912 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: In 2020/2021 in Germany, several non-pharmacological interventions were introduced to lower the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated to what extent knowledge of prior infection with SARS-CoV-2 or vaccination status influenced the use of personal protection measures (PPM). Further, we were interested in the effect of compliance with PPM on SARS-CoV-2 serostatus | ||
| 520 | |a METHODS: Data was based on a sequential, multilocal seroprevalence study (MuSPAD), carried out in eight locations from July 2020 to August 2021. We estimated the association between a known SARS-CoV-2 serostatus (reported positive PCR test or vaccination) and self-reported PPM behavior (hand hygiene, physical distancing, wearing face mask), just as the association of PPM compliance with seropositivity against nucleocapsid (NC), receptor-binding domain (RBD), and spike protein (S) antigens. We identified relevant variables and deduced adjustment sets with directed acyclic graphs (DAG), and applied mixed logistic regression | ||
| 520 | |a RESULTS: Out of the 22,297 participants (median age: 54 years, 43% male), 781 were classified as SARS-CoV-2-infected and 3,877 had a vaccinated immune response. Vaccinated individuals were less likely to keep 1.5 m distance [OR = 0.74 (95% CI: 0.57-0.97)] and only partly physically distanced [OR = 0.71 (95% CI: 0.58-0.87)]. Participants with self-reported positive PCR test had a lower chance of adhering partly to physical distancing [OR = 0.70 (95% CI: 0.50-0.99)] in comparison to the reference group. Higher odds of additionally wearing a face mask was observed in vaccinated [OR = 1.28 (95% CI: 1.08-1.51)] even if it was not obligatory. Overall, among unvaccinated participants, we found little evidence of lower odds of seropositivity given mask wearing [OR: 0.91 (95% CI: 0.71-1.16)], physical distancing [OR: 0.84 (95% CI: 0.59-1.20)] and no evidence for completely adhering to hand cleaning [OR: 0.97 (95% CI: 0.29-3.22)] | ||
| 520 | |a CONCLUSIONS: A known confirmed prior infection and vaccination may have the potential to influence adherence to PPM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Germany | |
| 650 | 4 | |a Non-pharmacological interventions | |
| 650 | 4 | |a Personal protection measures | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Seroepidemiologic studies | |
| 650 | 4 | |a Serostatus | |
| 700 | 1 | |a Harries, M |e verfasserin |4 aut | |
| 700 | 1 | |a Ortmann, J |e verfasserin |4 aut | |
| 700 | 1 | |a Krause, G |e verfasserin |4 aut | |
| 700 | 0 | |a MuSPAD Team |e verfasserin |4 aut | |
| 700 | 1 | |a Aigner, A |e verfasserin |4 aut | |
| 700 | 1 | |a Lange, B |e verfasserin |4 aut | |
| 700 | 1 | |a Strengert, Monika |e investigator |4 oth | |
| 700 | 1 | |a Castell, Stefanie |e investigator |4 oth | |
| 700 | 1 | |a Heise, Jana-Kirstin |e investigator |4 oth | |
| 700 | 1 | |a Hernandez, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Gornyk, Daniela |e investigator |4 oth | |
| 700 | 1 | |a Schlüter, Monike |e investigator |4 oth | |
| 700 | 1 | |a Kerrines, Tobias |e investigator |4 oth | |
| 700 | 1 | |a Schneiderhan-Marra, Nicole |e investigator |4 oth | |
| 700 | 1 | |a Dulovic, Alex |e investigator |4 oth | |
| 700 | 1 | |a Bojara, Gerhard |e investigator |4 oth | |
| 700 | 1 | |a Frank, Kerstin |e investigator |4 oth | |
| 700 | 1 | |a Gubbe, Knut |e investigator |4 oth | |
| 700 | 1 | |a Tonn, Torsten |e investigator |4 oth | |
| 700 | 1 | |a Kappert, Oliver |e investigator |4 oth | |
| 700 | 1 | |a Kern, Winfried V |e investigator |4 oth | |
| 700 | 1 | |a Illig, Thomas |e investigator |4 oth | |
| 700 | 1 | |a Klopp, Norman |e investigator |4 oth | |
| 700 | 1 | |a Roller, Gottfried |e investigator |4 oth | |
| 700 | 1 | |a Ziemons, Michael |e investigator |4 oth | |
| 700 | 1 | |a Rolle, Gottfried |e investigator |4 oth | |
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