Genomics for antimicrobial resistance surveillance to support infection prevention and control in health-care facilities
Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved..
Integration of genomic technologies into routine antimicrobial resistance (AMR) surveillance in health-care facilities has the potential to generate rapid, actionable information for patient management and inform infection prevention and control measures in near real time. However, substantial challenges limit the implementation of genomics for AMR surveillance in clinical settings. Through a workshop series and online consultation, international experts from across the AMR and pathogen genomics fields convened to review the evidence base underpinning the use of genomics for AMR surveillance in a range of settings. Here, we summarise the identified challenges and potential benefits of genomic AMR surveillance in health-care settings, and outline the recommendations of the working group to realise this potential. These recommendations include the definition of viable and cost-effective use cases for genomic AMR surveillance, strengthening training competencies (particularly in bioinformatics), and building capacity at local, national, and regional levels using hub and spoke models.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
The Lancet. Microbe - 4(2023), 12 vom: 27. Dez., Seite e1040-e1046 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jauneikaite, Elita [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 04.12.2023 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/S2666-5247(23)00282-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Integration of genomic technologies into routine antimicrobial resistance (AMR) surveillance in health-care facilities has the potential to generate rapid, actionable information for patient management and inform infection prevention and control measures in near real time. However, substantial challenges limit the implementation of genomics for AMR surveillance in clinical settings. Through a workshop series and online consultation, international experts from across the AMR and pathogen genomics fields convened to review the evidence base underpinning the use of genomics for AMR surveillance in a range of settings. Here, we summarise the identified challenges and potential benefits of genomic AMR surveillance in health-care settings, and outline the recommendations of the working group to realise this potential. These recommendations include the definition of viable and cost-effective use cases for genomic AMR surveillance, strengthening training competencies (particularly in bioinformatics), and building capacity at local, national, and regional levels using hub and spoke models | ||
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| 700 | 1 | |a Midega, Janet T |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Li Yang |e verfasserin |4 aut | |
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| 700 | 1 | |a Hopkins, Katie L |e verfasserin |4 aut | |
| 700 | 1 | |a Price, James R |e verfasserin |4 aut | |
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| 700 | 1 | |a Okeke, Iruka N |e verfasserin |4 aut | |
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| 700 | 1 | |a Peacock, Sharon J |e verfasserin |4 aut | |
| 700 | 1 | |a Feasey, Nicholas A |e verfasserin |4 aut | |
| 700 | 0 | |a SEDRIC Genomics Surveillance Working Group |e verfasserin |4 aut | |
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