Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension
Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cytokine concentration in 39 treatment-naïve patients (pulmonary arterial hypertension: N = 16, chronic thromboembolic PH: N = 15, PH due to lung disease: N = 8) and 12 control subjects using enzyme-linked immunoassays. Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0.33, P = 0.04), right atrial pressure (r = 0.38, P = 0.02), cardiac index (r = -0.34, P = 0.04), and right ventricular stroke work index (r = -0.47, P = 0.003). IL22RA2 concentration correlated with mean PAP (r = -0.32, P = 0.04) and serum N-terminal pro B-type natriuretic peptide level (r = -0.42, P = 0.01). VEGF concentration increased in patients upon clinical improvement (N = 16, P = 0.02). Circulating apelin is a novel biomarker of pre-capillary PH. Apelin and IL22RA2 levels are related to right ventricular function upon diagnosis of PH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:110 |
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| Enthalten in: |
Physiology international - 110(2023), 4 vom: 18. Dez., Seite 356-370 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Csósza, Györgyi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.12.2023 Date Revised 27.12.2023 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.1556/2060.2023.00264 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364674571 |
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| 245 | 1 | 0 | |a Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cytokine concentration in 39 treatment-naïve patients (pulmonary arterial hypertension: N = 16, chronic thromboembolic PH: N = 15, PH due to lung disease: N = 8) and 12 control subjects using enzyme-linked immunoassays. Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0.33, P = 0.04), right atrial pressure (r = 0.38, P = 0.02), cardiac index (r = -0.34, P = 0.04), and right ventricular stroke work index (r = -0.47, P = 0.003). IL22RA2 concentration correlated with mean PAP (r = -0.32, P = 0.04) and serum N-terminal pro B-type natriuretic peptide level (r = -0.42, P = 0.01). VEGF concentration increased in patients upon clinical improvement (N = 16, P = 0.02). Circulating apelin is a novel biomarker of pre-capillary PH. Apelin and IL22RA2 levels are related to right ventricular function upon diagnosis of PH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a cytokine | |
| 650 | 4 | |a growth hormone | |
| 650 | 4 | |a pulmonary hypertension | |
| 650 | 4 | |a right ventricular function | |
| 650 | 7 | |a Apelin |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a IL22RA2 protein, human |2 NLM | |
| 650 | 7 | |a Receptors, Interleukin |2 NLM | |
| 650 | 7 | |a Vascular Endothelial Growth Factor A |2 NLM | |
| 650 | 7 | |a VEGFA protein, human |2 NLM | |
| 700 | 1 | |a Szűcs, Gergő |e verfasserin |4 aut | |
| 700 | 1 | |a Rozgonyi, Zsolt |e verfasserin |4 aut | |
| 700 | 1 | |a Csoma, Balázs |e verfasserin |4 aut | |
| 700 | 1 | |a Losonczy, György |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Veronika |e verfasserin |4 aut | |
| 700 | 1 | |a Karlócai, Kristóf |e verfasserin |4 aut | |
| 700 | 1 | |a Lázár, Zsófia |e verfasserin |4 aut | |
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