Base-promoted tandem synthesis of 2-azaaryl indoline
A novel tandem method to synthesize 2-azaaryl indoline promoted by LiN(SiMe3)2 from 2-azaaryl methyl amine and 2-fluoro benzyl bromides was developed. Mechanistic investigation indicated that this tandem cyclization was initiated by selective benzyl C-SN2 substitution followed by an intramolecular SNAr reaction. Diverse 2-azaaryl indoles could also be obtained via simple functional transformations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Organic & biomolecular chemistry - 21(2023), 46 vom: 29. Nov., Seite 9133-9137 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Shuguang [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 29.11.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d3ob01444d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364660783 |
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| 520 | |a A novel tandem method to synthesize 2-azaaryl indoline promoted by LiN(SiMe3)2 from 2-azaaryl methyl amine and 2-fluoro benzyl bromides was developed. Mechanistic investigation indicated that this tandem cyclization was initiated by selective benzyl C-SN2 substitution followed by an intramolecular SNAr reaction. Diverse 2-azaaryl indoles could also be obtained via simple functional transformations | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Tan, Jiahong |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Quansheng |e verfasserin |4 aut | |
| 700 | 1 | |a Shang, Yongjia |e verfasserin |4 aut | |
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