Incidence, severity, and temporal development of oral complications in pediatric allogeneic hematopoietic stem cell transplant patients - a multicenter study
© 2023. The Author(s)..
PURPOSE: Oral mucositis is a common complication for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and causes pain and difficulties in functions like eating and swallowing, resulting in lower quality of life and greater need of treatment with opioids and parenteral nutrition. This prospective multicenter study focused on pediatric recipients of HSCT in the neutropenic phase concerning oral complications, timing, severity, and patient experience.
METHODS: The cohort comprised 68 patients, median age 11.1 years (IQR 6.3) receiving allogeneic HSCT at three clinical sites. Medical records were retrieved for therapy regimens, concomitant medications, oral and dental history, and subjective oral complaints. Calibrated dentists conducted an oral and dental investigation before HSCT. After HSCT graft infusion, study personnel made bedside assessments and patients filled out a questionnaire once or twice a week until neutrophil engraftment.
RESULTS: We followed 63 patients through the neutropenic phase until engraftment. 50% developed oral mucositis of grades 2-4. Peak severity occurred at 8-11 days after stem cell infusion. Altogether, 87% had subjective oral complaints. The temporal distribution of adverse events is similar to the development of oral mucositis. The most bothersome symptoms were blisters and oral ulcerations, including mucositis; 40% reported severe pain and major impact on activities of daily living despite continuous use of opioids.
CONCLUSION: This study highlights the burden of oral complications and their negative effect on the health and quality of life of HSCT recipients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 31(2023), 12 vom: 16. Nov., Seite 702 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Agholme, Monica Barr [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 21.12.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00520-023-08151-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364632275 |
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| 100 | 1 | |a Agholme, Monica Barr |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Incidence, severity, and temporal development of oral complications in pediatric allogeneic hematopoietic stem cell transplant patients - a multicenter study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 21.12.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: Oral mucositis is a common complication for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and causes pain and difficulties in functions like eating and swallowing, resulting in lower quality of life and greater need of treatment with opioids and parenteral nutrition. This prospective multicenter study focused on pediatric recipients of HSCT in the neutropenic phase concerning oral complications, timing, severity, and patient experience | ||
| 520 | |a METHODS: The cohort comprised 68 patients, median age 11.1 years (IQR 6.3) receiving allogeneic HSCT at three clinical sites. Medical records were retrieved for therapy regimens, concomitant medications, oral and dental history, and subjective oral complaints. Calibrated dentists conducted an oral and dental investigation before HSCT. After HSCT graft infusion, study personnel made bedside assessments and patients filled out a questionnaire once or twice a week until neutrophil engraftment | ||
| 520 | |a RESULTS: We followed 63 patients through the neutropenic phase until engraftment. 50% developed oral mucositis of grades 2-4. Peak severity occurred at 8-11 days after stem cell infusion. Altogether, 87% had subjective oral complaints. The temporal distribution of adverse events is similar to the development of oral mucositis. The most bothersome symptoms were blisters and oral ulcerations, including mucositis; 40% reported severe pain and major impact on activities of daily living despite continuous use of opioids | ||
| 520 | |a CONCLUSION: This study highlights the burden of oral complications and their negative effect on the health and quality of life of HSCT recipients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Dysphagia | |
| 650 | 4 | |a Hematological malignancies | |
| 650 | 4 | |a Nausea | |
| 650 | 4 | |a Neutropenia | |
| 650 | 4 | |a Oral mucositis | |
| 650 | 4 | |a Pain | |
| 650 | 4 | |a Patient-reported outcomes | |
| 650 | 4 | |a Prospective | |
| 700 | 1 | |a Dahllöf, Göran |e verfasserin |4 aut | |
| 700 | 1 | |a Törlén, Johan Karlsson |e verfasserin |4 aut | |
| 700 | 1 | |a Majorana, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Brennan, Michael T |e verfasserin |4 aut | |
| 700 | 1 | |a von Bültzingslöwen, Inger |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Poh Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Shijia |e verfasserin |4 aut | |
| 700 | 1 | |a Sim, Yu Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Catherine |e verfasserin |4 aut | |
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