Novel NIR-II fluorescent probes for biliary atresia imaging
© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V..
Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases. Therefore, it is very important to develop a simple, safe and reliable method for the early diagnosis of biliary atresia. Herein, a novel NIR-II fluorescence probe, HZL2, with high quantum yield, excellent biocompatibility, low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability. A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time, allowing for an early diagnosis of the disease. This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Acta pharmaceutica Sinica. B - 13(2023), 11 vom: 27. Nov., Seite 4578-4590 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zeng, Xiaodong [VerfasserIn] |
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| Links: |
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| Themen: |
Biliary atresia |
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| Anmerkungen: |
Date Revised 17.11.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.apsb.2023.07.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364613122 |
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| 520 | |a Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis is challenging because the clinical manifestations and laboratory tests of biliary atresia overlap with other cholestatic diseases. Therefore, it is very important to develop a simple, safe and reliable method for the early diagnosis of biliary atresia. Herein, a novel NIR-II fluorescence probe, HZL2, with high quantum yield, excellent biocompatibility, low cytotoxicity and rapid excretion through the liver and gallbladder was developed based on the oil/water partition coefficient and permeability. A simple fecal sample after injection of HZL2 can be used to efficiently identify the success of the mouse model of biliary atresia for the first time, allowing for an early diagnosis of the disease. This study not only developed a simple and safe method for the early diagnosis of biliary atresia with great potential in clinical translation but also provides a research tool for the development of pathogenesis and therapeutic medicines for biliary atresia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biliary atresia | |
| 650 | 4 | |a Early diagnosis | |
| 650 | 4 | |a Fluorescence imaging | |
| 650 | 4 | |a Hepatobiliary excretion | |
| 650 | 4 | |a Second near-infrared window | |
| 700 | 1 | |a Liao, Yuqin |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Qiusi |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Mingbo |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yishen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Weijing |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Xuechuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Yuling |e verfasserin |4 aut | |
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