Evaluating the effect of vitamin D supplementation on serum levels of 25-hydroxy vitamin D, 1,25-dihydroxy vitamin D, parathyroid hormone and renin-angiotensin-aldosterone system : a systematic review and meta-analysis of clinical trials
© 2023. The Author(s)..
BACKGROUND: Vitamin D, one of the most essential micronutrients, is crucial in various health outcomes. However, previous studies showed conflicting results and uncertainty about vitamin D supplementation's optimal dosage and duration. In this study, we aimed to evaluate the vitamin D supplements efficiency on serum levels of 25-hydroxy vitamin D (25(OH)D), 1,25-dihdroxy vitamin D (1,25(OH)2D), parathyroid hormone (PTH) and renin-angiotensin-aldosterone system (RAAS) in adults.
METHODS: A systematic analysis of eligible and relevant randomized-controlled trials (RCT) published before April 2023 assessing the effect of vitamin D supplementations applied. The studies were identified by searching several databases, including Pubmed, Scopus, Web of Science, ProQuest, and Cochrane Register of controlled trials.
RESULTS: Five eligible RCTs with 346 participants in the intervention and 352 participants in the control group were assessed in our project. According to the results, there was a substantial change in 25(OH)D (SMD: 2.2, I2: 92.3, 95% Confidence Interval (CI): 1.38-3.02, P-value: 0.048) and 1,25(OH)2D (SMD:1.23, I2: 86.3, 95% CI: 0.01- 2.44, P-value < 0.010) affected by vitamin D intervention. Regarding Parathyroid hormone (PTH), however, vitamin D intervention showed a remarkable decrease (SMD: -0.75, I2: 82.4, 95% CI: (-1.3)-(-0.18), P-value < 0.010). Moreover, sensitivity analysis showed significant publication bias in terms of 25(OH)D.
CONCLUSION: Vitamin D supplements significantly increase the serum levels of 25(OH)D and 1,25(OH)2D and decrease PTH levels. While some studies reported decreasing effect of vitamin D supplements on RAAS activity, some reported no changes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
BMC nutrition - 9(2023), 1 vom: 15. Nov., Seite 132 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Khodadadiyan, Alireza [VerfasserIn] |
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| Links: |
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| Themen: |
Calcitriol |
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| Anmerkungen: |
Date Revised 24.11.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s40795-023-00786-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364603291 |
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| 100 | 1 | |a Khodadadiyan, Alireza |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluating the effect of vitamin D supplementation on serum levels of 25-hydroxy vitamin D, 1,25-dihydroxy vitamin D, parathyroid hormone and renin-angiotensin-aldosterone system |b a systematic review and meta-analysis of clinical trials |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Vitamin D, one of the most essential micronutrients, is crucial in various health outcomes. However, previous studies showed conflicting results and uncertainty about vitamin D supplementation's optimal dosage and duration. In this study, we aimed to evaluate the vitamin D supplements efficiency on serum levels of 25-hydroxy vitamin D (25(OH)D), 1,25-dihdroxy vitamin D (1,25(OH)2D), parathyroid hormone (PTH) and renin-angiotensin-aldosterone system (RAAS) in adults | ||
| 520 | |a METHODS: A systematic analysis of eligible and relevant randomized-controlled trials (RCT) published before April 2023 assessing the effect of vitamin D supplementations applied. The studies were identified by searching several databases, including Pubmed, Scopus, Web of Science, ProQuest, and Cochrane Register of controlled trials | ||
| 520 | |a RESULTS: Five eligible RCTs with 346 participants in the intervention and 352 participants in the control group were assessed in our project. According to the results, there was a substantial change in 25(OH)D (SMD: 2.2, I2: 92.3, 95% Confidence Interval (CI): 1.38-3.02, P-value: 0.048) and 1,25(OH)2D (SMD:1.23, I2: 86.3, 95% CI: 0.01- 2.44, P-value < 0.010) affected by vitamin D intervention. Regarding Parathyroid hormone (PTH), however, vitamin D intervention showed a remarkable decrease (SMD: -0.75, I2: 82.4, 95% CI: (-1.3)-(-0.18), P-value < 0.010). Moreover, sensitivity analysis showed significant publication bias in terms of 25(OH)D | ||
| 520 | |a CONCLUSION: Vitamin D supplements significantly increase the serum levels of 25(OH)D and 1,25(OH)2D and decrease PTH levels. While some studies reported decreasing effect of vitamin D supplements on RAAS activity, some reported no changes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Calcitriol | |
| 650 | 4 | |a Ergocalciferols | |
| 650 | 4 | |a Renin-Angiotensin System | |
| 650 | 4 | |a Vitamin D | |
| 700 | 1 | |a Rahmanian, Mahdi |e verfasserin |4 aut | |
| 700 | 1 | |a Shekouh, Dorsa |e verfasserin |4 aut | |
| 700 | 1 | |a Golmohammadi, Melika |e verfasserin |4 aut | |
| 700 | 1 | |a Ghaedi, Arshin |e verfasserin |4 aut | |
| 700 | 1 | |a Bazrgar, Aida |e verfasserin |4 aut | |
| 700 | 1 | |a Sayadi, Mehrab |e verfasserin |4 aut | |
| 700 | 1 | |a Bazrafshan, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Heydari, Aigin |e verfasserin |4 aut | |
| 700 | 1 | |a Bazrafshan Drissi, Hamed |e verfasserin |4 aut | |
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