Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity
© 2023. The Author(s)..
Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula: see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula: see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula: see text] values. We found that the correlation of [Formula: see text] with the reference standard ([Formula: see text]/[Formula: see text] ratio) improves substantially when excluding [Formula: see text] and refer to this measure as [Formula: see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula: see text] is predictive of mortality, and compare the sample sizes required for trials using four different outcome measures. We show that a significant difference in outcome could be detected with the smallest sample size using [Formula: see text]. We demonstrate that [Formula: see text] is an effective intermediate outcome measure in COVID-19. It is a non-invasive measurement, representative of disease severity and provides greater statistical power.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Nature communications - 14(2023), 1 vom: 15. Nov., Seite 7374 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Swets, Maaike C [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 17.11.2023 Date Revised 10.02.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41467-023-42205-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364598514 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364598514 | ||
| 003 | DE-627 | ||
| 005 | 20240210232912.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-023-42205-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1287.xml |
| 035 | |a (DE-627)NLM364598514 | ||
| 035 | |a (NLM)37968269 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Swets, Maaike C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.11.2023 | ||
| 500 | |a Date Revised 10.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula: see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula: see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula: see text] values. We found that the correlation of [Formula: see text] with the reference standard ([Formula: see text]/[Formula: see text] ratio) improves substantially when excluding [Formula: see text] and refer to this measure as [Formula: see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula: see text] is predictive of mortality, and compare the sample sizes required for trials using four different outcome measures. We show that a significant difference in outcome could be detected with the smallest sample size using [Formula: see text]. We demonstrate that [Formula: see text] is an effective intermediate outcome measure in COVID-19. It is a non-invasive measurement, representative of disease severity and provides greater statistical power | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Kerr, Steven |e verfasserin |4 aut | |
| 700 | 1 | |a Scott-Brown, James |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Adam B |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Rishi |e verfasserin |4 aut | |
| 700 | 1 | |a Millar, Jonathan E |e verfasserin |4 aut | |
| 700 | 1 | |a Spata, Enti |e verfasserin |4 aut | |
| 700 | 1 | |a McCurrach, Fiona |e verfasserin |4 aut | |
| 700 | 1 | |a Bretherick, Andrew D |e verfasserin |4 aut | |
| 700 | 1 | |a Docherty, Annemarie |e verfasserin |4 aut | |
| 700 | 1 | |a Harrison, David |e verfasserin |4 aut | |
| 700 | 1 | |a Rowan, Kathy |e verfasserin |4 aut | |
| 700 | 1 | |a Young, Neil |e verfasserin |4 aut | |
| 700 | 0 | |a ISARIC4C Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Groeneveld, Geert H |e verfasserin |4 aut | |
| 700 | 1 | |a Dunning, Jake |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen-Van-Tam, Jonathan S |e verfasserin |4 aut | |
| 700 | 1 | |a Openshaw, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Horby, Peter W |e verfasserin |4 aut | |
| 700 | 1 | |a Harrison, Ewen |e verfasserin |4 aut | |
| 700 | 1 | |a Staplin, Natalie |e verfasserin |4 aut | |
| 700 | 1 | |a Semple, Malcolm G |e verfasserin |4 aut | |
| 700 | 1 | |a Lone, Nazir |e verfasserin |4 aut | |
| 700 | 1 | |a Baillie, J Kenneth |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 14(2023), 1 vom: 15. Nov., Seite 7374 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2023 |g number:1 |g day:15 |g month:11 |g pages:7374 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-023-42205-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2023 |e 1 |b 15 |c 11 |h 7374 | ||