TB diagnostic insights, progress made on point of care diagnostics and bioinformatics as an additional tool for improvement
Copyright © 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved..
Despite major efforts made to control tuberculosis disease (TB), this disease continues to present a major global health challenge and drug resistance is continuously growing. TB is caused by Mycobacterium tuberculosis and spreads exclusively via human-to-human contact transmission. Therefore, early detection and diagnosis for proper treatment with active TB have a great impact on public health. Regardless, most people in developing countries with TB or TB-associated symptoms do not have access to an adequate initial diagnosis. Available bacteriologic-based techniques are either inefficient or may require a longer turnaround time from the laboratory. Contemporarily, non-bacteriologic based methods have both questionable sensitivity and specificity and while others cannot distinguish between active and latent TB. Thus, additional efforts have been made to find accurate diagnostic tests for TB. Herein, we review the available methods used for TB diagnosis, and in addition, we explore point of care (POC) diagnostics as an alternative way to develop TB diagnostic tests and further evaluate whether bioinformatics can be used as an additional screening tool for identification of possible TB biomarkers for the development of POC TB diagnostics, which is part of our research focus.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
|---|---|
| Enthalten in: |
The Indian journal of tuberculosis - 70(2023), 4 vom: 21. Okt., Seite 468-474 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tjale, Mabotse A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ijtb.2023.03.023 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364596341 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364596341 | ||
| 003 | DE-627 | ||
| 005 | 20240214232927.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijtb.2023.03.023 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1293.xml |
| 035 | |a (DE-627)NLM364596341 | ||
| 035 | |a (NLM)37968053 | ||
| 035 | |a (PII)S0019-5707(23)00057-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tjale, Mabotse A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a TB diagnostic insights, progress made on point of care diagnostics and bioinformatics as an additional tool for improvement |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.02.2024 | ||
| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Despite major efforts made to control tuberculosis disease (TB), this disease continues to present a major global health challenge and drug resistance is continuously growing. TB is caused by Mycobacterium tuberculosis and spreads exclusively via human-to-human contact transmission. Therefore, early detection and diagnosis for proper treatment with active TB have a great impact on public health. Regardless, most people in developing countries with TB or TB-associated symptoms do not have access to an adequate initial diagnosis. Available bacteriologic-based techniques are either inefficient or may require a longer turnaround time from the laboratory. Contemporarily, non-bacteriologic based methods have both questionable sensitivity and specificity and while others cannot distinguish between active and latent TB. Thus, additional efforts have been made to find accurate diagnostic tests for TB. Herein, we review the available methods used for TB diagnosis, and in addition, we explore point of care (POC) diagnostics as an alternative way to develop TB diagnostic tests and further evaluate whether bioinformatics can be used as an additional screening tool for identification of possible TB biomarkers for the development of POC TB diagnostics, which is part of our research focus | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Mycobacterium tuberculosis | |
| 650 | 4 | |a Point of care (POC) | |
| 650 | 4 | |a Tuberculosis (TB) | |
| 700 | 1 | |a Ombinda-Lemboumba, Saturnin |e verfasserin |4 aut | |
| 700 | 1 | |a Maphanga, Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Mthunzi-Kufa, Patience |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Indian journal of tuberculosis |d 2007 |g 70(2023), 4 vom: 21. Okt., Seite 468-474 |w (DE-627)NLM169864154 |x 0019-5707 |7 nnns |
| 773 | 1 | 8 | |g volume:70 |g year:2023 |g number:4 |g day:21 |g month:10 |g pages:468-474 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijtb.2023.03.023 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 70 |j 2023 |e 4 |b 21 |c 10 |h 468-474 | ||