Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β-hydroxybutyrate in gut environments
IMPORTANCE: Even though studying on the possible involvement of extracellular vesicles (EVs) in host-microbe interactions, how these relationships mediate host physiology has not clarified yet. Our current findings provide insights into the encouraging benefits of dietary source-derived EVs and microRNAs (miRNAs) on organic acid production and ultimately stimulating gut microbiome for human health, suggesting that supplementation of dietary colostrum EVs and miRNAs is a novel preventive strategy for the treatment of inflammatory bowel disease.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Microbiology spectrum - 11(2023), 6 vom: 12. Dez., Seite e0012123 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mun, Daye [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
3-Hydroxybutyric Acid |
|---|
| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1128/spectrum.00121-23 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364578483 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364578483 | ||
| 003 | DE-627 | ||
| 005 | 20231227133215.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1128/spectrum.00121-23 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1230.xml |
| 035 | |a (DE-627)NLM364578483 | ||
| 035 | |a (NLM)37966243 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mun, Daye |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β-hydroxybutyrate in gut environments |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.12.2023 | ||
| 500 | |a Date Revised 16.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IMPORTANCE: Even though studying on the possible involvement of extracellular vesicles (EVs) in host-microbe interactions, how these relationships mediate host physiology has not clarified yet. Our current findings provide insights into the encouraging benefits of dietary source-derived EVs and microRNAs (miRNAs) on organic acid production and ultimately stimulating gut microbiome for human health, suggesting that supplementation of dietary colostrum EVs and miRNAs is a novel preventive strategy for the treatment of inflammatory bowel disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a bovine colostrum | |
| 650 | 4 | |a bta-let-7a-5p | |
| 650 | 4 | |a extracellular vesicles | |
| 650 | 4 | |a metabolome | |
| 650 | 4 | |a microbiome | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 650 | 7 | |a 3-Hydroxybutyric Acid |2 NLM | |
| 650 | 7 | |a TZP1275679 |2 NLM | |
| 700 | 1 | |a Kang, Minkyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Minhye |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Hye Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, An Na |e verfasserin |4 aut | |
| 700 | 1 | |a Ryu, Sangdon |e verfasserin |4 aut | |
| 700 | 1 | |a Unno, Tatsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Maburutse, Brighton E |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Sangnam |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Younghoon |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Microbiology spectrum |d 2013 |g 11(2023), 6 vom: 12. Dez., Seite e0012123 |w (DE-627)NLM241847044 |x 2165-0497 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2023 |g number:6 |g day:12 |g month:12 |g pages:e0012123 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1128/spectrum.00121-23 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2023 |e 6 |b 12 |c 12 |h e0012123 | ||