Adaptive decision-making depends on pupil-linked arousal in rats performing tactile discrimination tasks
Perceptual decision-making is a dynamic cognitive process and is shaped by many factors, including behavioral state, reward contingency, and sensory environment. To understand the extent to which adaptive behavior in decision-making is dependent on pupil-linked arousal, we trained head-fixed rats to perform perceptual decision-making tasks and systematically manipulated the probability of Go and No-go stimuli while simultaneously measuring their pupil size in the tasks. Our data demonstrated that the animals adaptively modified their behavior in response to the changes in the sensory environment. The response probability to both Go and No-go stimuli decreased as the probability of the Go stimulus being presented decreased. Analyses within the signal detection theory framework showed that while the animals' perceptual sensitivity was invariant, their decision criterion increased as the probability of the Go stimulus decreased. Simulation results indicated that the adaptive increase in the decision criterion will increase possible water rewards during the task. Moreover, the adaptive decision-making is dependent on pupil-linked arousal as the increase in the decision criterion was the largest during low pupil-linked arousal periods. Taken together, our results demonstrated that the rats were able to adjust their decision-making to maximize rewards in the tasks, and that adaptive behavior in perceptual decision-making is dependent on pupil-linked arousal.NEW & NOTEWORTHY Perceptual decision-making is a dynamic cognitive process and is shaped by many factors. However, the extent to which changes in sensory environment result in adaptive decision-making remains poorly understood. Our data provided new experimental evidence demonstrating that the rats were able to adaptively modify their decision criterion to maximize water reward in response to changes in the statistics of the sensory environment. Furthermore, the adaptive decision-making is dependent on pupil-linked arousal.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
Journal of neurophysiology - 130(2023), 6 vom: 01. Dez., Seite 1541-1551 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Narasimhan, Shreya [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 19.01.2024 published: Print-Electronic figshare: 10.6084/m9.figshare.24520669 Citation Status MEDLINE |
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| doi: |
10.1152/jn.00309.2022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364563605 |
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| 520 | |a Perceptual decision-making is a dynamic cognitive process and is shaped by many factors, including behavioral state, reward contingency, and sensory environment. To understand the extent to which adaptive behavior in decision-making is dependent on pupil-linked arousal, we trained head-fixed rats to perform perceptual decision-making tasks and systematically manipulated the probability of Go and No-go stimuli while simultaneously measuring their pupil size in the tasks. Our data demonstrated that the animals adaptively modified their behavior in response to the changes in the sensory environment. The response probability to both Go and No-go stimuli decreased as the probability of the Go stimulus being presented decreased. Analyses within the signal detection theory framework showed that while the animals' perceptual sensitivity was invariant, their decision criterion increased as the probability of the Go stimulus decreased. Simulation results indicated that the adaptive increase in the decision criterion will increase possible water rewards during the task. Moreover, the adaptive decision-making is dependent on pupil-linked arousal as the increase in the decision criterion was the largest during low pupil-linked arousal periods. Taken together, our results demonstrated that the rats were able to adjust their decision-making to maximize rewards in the tasks, and that adaptive behavior in perceptual decision-making is dependent on pupil-linked arousal.NEW & NOTEWORTHY Perceptual decision-making is a dynamic cognitive process and is shaped by many factors. However, the extent to which changes in sensory environment result in adaptive decision-making remains poorly understood. Our data provided new experimental evidence demonstrating that the rats were able to adaptively modify their decision criterion to maximize water reward in response to changes in the statistics of the sensory environment. Furthermore, the adaptive decision-making is dependent on pupil-linked arousal | ||
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| 650 | 4 | |a Go/No-go tactile discrimination task | |
| 650 | 4 | |a adaptive decision-making | |
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| 700 | 1 | |a Wang, Qi |e verfasserin |4 aut | |
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