Sequential cellular and humoral responses after repetitive COVID-19 vaccination in patients treated with anti-CD20 antibodies
© 2023 British Society for Haematology and John Wiley & Sons Ltd..
Patients treated with anti-CD20 antibodies for haematological disorders have insufficient immune responses to mRNA COVID-19 vaccines; however, relevant sequential data are lacking. We sequentially evaluated the humoral and cellular immune responses in 22 patients who had received anti-CD20 antibodies within 12 months before the first vaccination, before and after the third and fourth vaccinations. Humoral responses improved gradually, along with the resolution of B-cell depletion. A steady increase was noted in cellular responses, regardless of the B-cell status. Our findings suggest the potential benefit of repeated vaccinations in these patients until B-cell recovery is confirmed while enhancing cellular responses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:204 |
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| Enthalten in: |
British journal of haematology - 204(2024), 3 vom: 14. März, Seite 821-825 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nishikubo, Masashi [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies |
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| Anmerkungen: |
Date Completed 14.03.2024 Date Revised 14.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/bjh.19207 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364560290 |
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| 520 | |a © 2023 British Society for Haematology and John Wiley & Sons Ltd. | ||
| 520 | |a Patients treated with anti-CD20 antibodies for haematological disorders have insufficient immune responses to mRNA COVID-19 vaccines; however, relevant sequential data are lacking. We sequentially evaluated the humoral and cellular immune responses in 22 patients who had received anti-CD20 antibodies within 12 months before the first vaccination, before and after the third and fourth vaccinations. Humoral responses improved gradually, along with the resolution of B-cell depletion. A steady increase was noted in cellular responses, regardless of the B-cell status. Our findings suggest the potential benefit of repeated vaccinations in these patients until B-cell recovery is confirmed while enhancing cellular responses | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Shimomura, Yoshimitsu |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Ryusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Maruoka, Hayato |e verfasserin |4 aut | |
| 700 | 1 | |a Nasu, Seiko |e verfasserin |4 aut | |
| 700 | 1 | |a Sakizono, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Nagai, Yuya |e verfasserin |4 aut | |
| 700 | 1 | |a Hiramoto, Nobuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yonetani, Noboru |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Tadakazu |e verfasserin |4 aut | |
| 700 | 1 | |a Miyakoshi, Chisato |e verfasserin |4 aut | |
| 700 | 1 | |a Doi, Asako |e verfasserin |4 aut | |
| 700 | 1 | |a Ishikawa, Takayuki |e verfasserin |4 aut | |
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