Pyogenic spondylodiscitis in HIV-positive patients under antiretroviral therapy : A case series
Background: The incidence of pyogenic spondylodiscitis has been increasing in countries of Europe and North America, probably due to an increasing number of persons with risk factors for this infection. It is unclear whether HIV infection in the era of antiretroviral therapy (ART) increases the risk for spondylodiscitis. Method: We present 7 cases of pyogenic spondylodiscitis of the cervical, thoracic, and lumbar spine in six individuals living with HIV under ART with suppressed viral load. Results: All patients presented with severe non-radicular pain and elevated inflammatory markers. Diagnosis was confirmed by magnetic resonance imaging (MRI) scan and isolation of the pathogen. Staphylococcus aureus was the causative pathogen in five patients. One patient suffered from an infection with Klebsiella pneumoniae followed by a mixed infection with Cutibacterium acnes and Bacillus circulans 18 months later. All patients needed surgical intervention, and the mean duration of antibiotic treatment was 17 weeks (range 12-26). Five patients recovered fully, including two persons who also suffered from endocarditis. One patient died from multi-organ failure. Conclusion: Spondylodiscitis may be seen more frequently in persons living with HIV as they grow older and suffer from comorbidities which put them at risk for this infection. HIV physicians should be aware of the infection and its risk factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
International journal of STD & AIDS - 35(2024), 3 vom: 29. März, Seite 234-239 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kitchen, Maria [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/09564624231211019 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364550376 |
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| 100 | 1 | |a Kitchen, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pyogenic spondylodiscitis in HIV-positive patients under antiretroviral therapy |b A case series |
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| 500 | |a Date Revised 04.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: The incidence of pyogenic spondylodiscitis has been increasing in countries of Europe and North America, probably due to an increasing number of persons with risk factors for this infection. It is unclear whether HIV infection in the era of antiretroviral therapy (ART) increases the risk for spondylodiscitis. Method: We present 7 cases of pyogenic spondylodiscitis of the cervical, thoracic, and lumbar spine in six individuals living with HIV under ART with suppressed viral load. Results: All patients presented with severe non-radicular pain and elevated inflammatory markers. Diagnosis was confirmed by magnetic resonance imaging (MRI) scan and isolation of the pathogen. Staphylococcus aureus was the causative pathogen in five patients. One patient suffered from an infection with Klebsiella pneumoniae followed by a mixed infection with Cutibacterium acnes and Bacillus circulans 18 months later. All patients needed surgical intervention, and the mean duration of antibiotic treatment was 17 weeks (range 12-26). Five patients recovered fully, including two persons who also suffered from endocarditis. One patient died from multi-organ failure. Conclusion: Spondylodiscitis may be seen more frequently in persons living with HIV as they grow older and suffer from comorbidities which put them at risk for this infection. HIV physicians should be aware of the infection and its risk factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cutibacterium acnes | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Klebsiella pneumoniae | |
| 650 | 4 | |a Pyogenic spondylodiscitis | |
| 650 | 4 | |a Staphylococcus aureus | |
| 650 | 4 | |a epidural abscess | |
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| 700 | 1 | |a Gasslitter, Irina |e verfasserin |4 aut | |
| 700 | 1 | |a Gisinger, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Deeg, Johannes |e verfasserin |4 aut | |
| 700 | 1 | |a Rieger, Armin |e verfasserin |4 aut | |
| 700 | 1 | |a Sarcletti, Mario |e verfasserin |4 aut | |
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