Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG..
Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9-dihydroxyguaian-10(14)-en-12-olide (10) showed explicit anti-inflammatory activity in rodent paw edema and MPO assignment. The findings of this study showed that the α-methylene γ-lactone moiety does not always guarantee an anti-inflammatory effect, but the presence of proline at the C3 of the lactone ring improves the binding of sesquiterpene lactones with MPO isoenzymes, resulting in a more potent inhibition.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
|---|---|
| Enthalten in: |
Inflammopharmacology - 32(2024), 2 vom: 14. Apr., Seite 1489-1498 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Perveen, Shagufta [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 11.04.2024 Date Revised 11.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10787-023-01375-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364543248 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364543248 | ||
| 003 | DE-627 | ||
| 005 | 20240411232144.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10787-023-01375-x |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1372.xml |
| 035 | |a (DE-627)NLM364543248 | ||
| 035 | |a (NLM)37962696 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Perveen, Shagufta |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.04.2024 | ||
| 500 | |a Date Revised 11.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. | ||
| 520 | |a Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9-dihydroxyguaian-10(14)-en-12-olide (10) showed explicit anti-inflammatory activity in rodent paw edema and MPO assignment. The findings of this study showed that the α-methylene γ-lactone moiety does not always guarantee an anti-inflammatory effect, but the presence of proline at the C3 of the lactone ring improves the binding of sesquiterpene lactones with MPO isoenzymes, resulting in a more potent inhibition | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anvillea garcinii | |
| 650 | 4 | |a Anti-inflammatory potential | |
| 650 | 4 | |a Sesquiterpene lactones | |
| 650 | 4 | |a Structure–activity relationship | |
| 650 | 7 | |a eudesmanolide |2 NLM | |
| 650 | 7 | |a Sesquiterpenes, Guaiane |2 NLM | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Sesquiterpenes |2 NLM | |
| 650 | 7 | |a Lactones |2 NLM | |
| 700 | 1 | |a Hamedi, Azadeh |e verfasserin |4 aut | |
| 700 | 1 | |a Pasdaran, Ardalan |e verfasserin |4 aut | |
| 700 | 1 | |a Heidari, Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Azam, Muhammad Shafiq Ul |e verfasserin |4 aut | |
| 700 | 1 | |a Tabassum, Sobia |e verfasserin |4 aut | |
| 700 | 1 | |a Mehmood, Rashad |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Jiangnan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Inflammopharmacology |d 1996 |g 32(2024), 2 vom: 14. Apr., Seite 1489-1498 |w (DE-627)NLM090686616 |x 1568-5608 |7 nnns |
| 773 | 1 | 8 | |g volume:32 |g year:2024 |g number:2 |g day:14 |g month:04 |g pages:1489-1498 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10787-023-01375-x |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 32 |j 2024 |e 2 |b 14 |c 04 |h 1489-1498 | ||