Cardiovascular risk prediction with cardio-ankle vascular index in the malaysian cohort study
Copyright © 2023. Published by Elsevier Inc..
The cardio-ankle vascular index (CAVI) is an important parameter assessing arterial function. It reflects arterial stiffness from the origin of the aorta to the ankle, and the algorithm is blood pressure independent. Recent data have suggested that a high CAVI score can predict future cardiovascular disease (CVD) events; however, to date, no study has been done in Malaysia. We conducted a prospective study on 2,168 The Malaysian Cohort (TMC) CVD-free participants (971 men and 1,197 women; mean age 51.64 ± 8.38 years old) recruited from November 2011 to March 2012. This participants were followed-up until the emergence of CVD incidence and mortality (endpoint between May to September 2019; duration of 7.5 years). Eligible participants were assessed based on CAVI baseline measurement which categorised them into low (CAVI <9.0) and high (CAVI ≥ 9.0) scores. The CVD events in the group with high CAVI (6.5 %) were significantly higher than in the low CAVI (2.6 %) group (p < 0.05). CAVI with cut-off point ≥ 9.0 was a significant independent predictor for CVD event even after adjustment for male, ethnicity, age, and intermediate atherogenic index of plasma (AIP). Those who have higher CAVI have 78 % significantly higher risk of developing CVD compared to those with the low CAVI (adjusted OR [95 % CI] = 1.78 [1.04 - 3.05], p =0.035). In addition, the participants with higher CAVI have significantly lower survival probability than those who have lower CAVI values. Thus, this study indicated that the CAVI can predict CVD event independently among the TMC participants.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Current problems in cardiology - 49(2024), 3 vom: 01. Feb., Seite 102192 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abdullah, Noraidatulakma [VerfasserIn] |
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| Links: |
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| Themen: |
Cardio-ankle vascular index |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cpcardiol.2023.102192 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364444452 |
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| 520 | |a The cardio-ankle vascular index (CAVI) is an important parameter assessing arterial function. It reflects arterial stiffness from the origin of the aorta to the ankle, and the algorithm is blood pressure independent. Recent data have suggested that a high CAVI score can predict future cardiovascular disease (CVD) events; however, to date, no study has been done in Malaysia. We conducted a prospective study on 2,168 The Malaysian Cohort (TMC) CVD-free participants (971 men and 1,197 women; mean age 51.64 ± 8.38 years old) recruited from November 2011 to March 2012. This participants were followed-up until the emergence of CVD incidence and mortality (endpoint between May to September 2019; duration of 7.5 years). Eligible participants were assessed based on CAVI baseline measurement which categorised them into low (CAVI <9.0) and high (CAVI ≥ 9.0) scores. The CVD events in the group with high CAVI (6.5 %) were significantly higher than in the low CAVI (2.6 %) group (p < 0.05). CAVI with cut-off point ≥ 9.0 was a significant independent predictor for CVD event even after adjustment for male, ethnicity, age, and intermediate atherogenic index of plasma (AIP). Those who have higher CAVI have 78 % significantly higher risk of developing CVD compared to those with the low CAVI (adjusted OR [95 % CI] = 1.78 [1.04 - 3.05], p =0.035). In addition, the participants with higher CAVI have significantly lower survival probability than those who have lower CAVI values. Thus, this study indicated that the CAVI can predict CVD event independently among the TMC participants | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Cardiovascular disease event | |
| 650 | 4 | |a Cardiovascular disease mortality | |
| 700 | 1 | |a Blin, Joan Anak |e verfasserin |4 aut | |
| 700 | 1 | |a Kamalul Arifin, Azwa Shawani |e verfasserin |4 aut | |
| 700 | 1 | |a Abd Jalal, Nazihah |e verfasserin |4 aut | |
| 700 | 1 | |a Ismail, Norliza |e verfasserin |4 aut | |
| 700 | 1 | |a Mohd Yusof, Nurul Ain |e verfasserin |4 aut | |
| 700 | 1 | |a Abdullah, Mohd Shaharom |e verfasserin |4 aut | |
| 700 | 1 | |a Husin, Nurul Faeizah |e verfasserin |4 aut | |
| 700 | 1 | |a Dauni, Andri |e verfasserin |4 aut | |
| 700 | 1 | |a Kamaruddin, Mohd Arman |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammed Nawi, Azmawati |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Norfazilah |e verfasserin |4 aut | |
| 700 | 1 | |a Hassan, Mohd Rohaizat |e verfasserin |4 aut | |
| 700 | 1 | |a Jamal, Rahman |e verfasserin |4 aut | |
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