Higher serum concentrations of PFAS among pesticide exposed female greenhouse workers
Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved..
BACKGROUND: Long-chained poly- and perfluoroalkyl substances (PFAS) have been used in pesticide formulations but their potential impact on human PFAS exposure has not been addressed.
OBJECTIVES: To investigate if occupationally pesticide exposed female greenhouse workers in Denmark had higher serum concentrations of PFAS than a comparable background population.
METHODS: Serum samples collected between 1996 and 2001 from 181 pregnant greenhouse workers and a contemporary urban population of 48 pregnant women were analyzed for eight PFAS: perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorooctane sulfonamide (FOSA), N-methyl perfluorooctane sulfonamido acetic acid (N-MeFOSAA), and N-ethyl perfluorooctane sulfonamido acetic acid (N-EtFOSAA).
RESULTS: The concentrations of PFOA, PFOS, and the PFOS precursors N-MeFOSAA, N-EtFOSAA, and FOSA were higher, and PFHxS was lower, among greenhouse workers than the comparison population. After adjusting for age and parity, serum concentrations of N-MeFOSAA, N-EtFOSAA, and FOSA were 2-to-3-fold higher, and the major PFAS in serum, PFOS and PFOA, were 30-50 % higher among the greenhouse workers.
CONCLUSION: Higher serum concentrations of some legacy PFAS among female greenhouse workers indicate that exposure to pesticides is a potential pathway of exposure. Although PFAS use in pesticide applications may appear to be a minor source of exposure for the general population, this pathway deserves attention in risk assessment.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 2023 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:255 |
|---|---|
| Enthalten in: |
International journal of hygiene and environmental health - 255(2023) vom: 06. Jan., Seite 114292 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Andersen, Helle Raun [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 06.12.2023 Date Revised 06.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ijheh.2023.114292 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364440465 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364440465 | ||
| 003 | DE-627 | ||
| 005 | 20231226095434.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijheh.2023.114292 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1214.xml |
| 035 | |a (DE-627)NLM364440465 | ||
| 035 | |a (NLM)37952389 | ||
| 035 | |a (PII)S1438-4639(23)00183-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Andersen, Helle Raun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Higher serum concentrations of PFAS among pesticide exposed female greenhouse workers |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.12.2023 | ||
| 500 | |a Date Revised 06.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved. | ||
| 520 | |a BACKGROUND: Long-chained poly- and perfluoroalkyl substances (PFAS) have been used in pesticide formulations but their potential impact on human PFAS exposure has not been addressed | ||
| 520 | |a OBJECTIVES: To investigate if occupationally pesticide exposed female greenhouse workers in Denmark had higher serum concentrations of PFAS than a comparable background population | ||
| 520 | |a METHODS: Serum samples collected between 1996 and 2001 from 181 pregnant greenhouse workers and a contemporary urban population of 48 pregnant women were analyzed for eight PFAS: perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorooctane sulfonamide (FOSA), N-methyl perfluorooctane sulfonamido acetic acid (N-MeFOSAA), and N-ethyl perfluorooctane sulfonamido acetic acid (N-EtFOSAA) | ||
| 520 | |a RESULTS: The concentrations of PFOA, PFOS, and the PFOS precursors N-MeFOSAA, N-EtFOSAA, and FOSA were higher, and PFHxS was lower, among greenhouse workers than the comparison population. After adjusting for age and parity, serum concentrations of N-MeFOSAA, N-EtFOSAA, and FOSA were 2-to-3-fold higher, and the major PFAS in serum, PFOS and PFOA, were 30-50 % higher among the greenhouse workers | ||
| 520 | |a CONCLUSION: Higher serum concentrations of some legacy PFAS among female greenhouse workers indicate that exposure to pesticides is a potential pathway of exposure. Although PFAS use in pesticide applications may appear to be a minor source of exposure for the general population, this pathway deserves attention in risk assessment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Exposure | |
| 650 | 4 | |a Greenhouse workers | |
| 650 | 4 | |a Occupational | |
| 650 | 4 | |a PFAS | |
| 650 | 4 | |a Pesticides | |
| 650 | 4 | |a Serum concentrations | |
| 650 | 7 | |a perfluorooctane |2 NLM | |
| 650 | 7 | |a 6P60ZBK0QL |2 NLM | |
| 650 | 7 | |a N-ethyl perfluorooctane sulfonamido acetate |2 NLM | |
| 650 | 7 | |a 2-(N-methylperfluorooctanesulfonamido)acetic acid |2 NLM | |
| 650 | 7 | |a Environmental Pollutants |2 NLM | |
| 650 | 7 | |a perfluorooctanoic acid |2 NLM | |
| 650 | 7 | |a 947VD76D3L |2 NLM | |
| 650 | 7 | |a Fluorocarbons |2 NLM | |
| 650 | 7 | |a perfluorooctane sulfonic acid |2 NLM | |
| 650 | 7 | |a 9H2MAI21CL |2 NLM | |
| 650 | 7 | |a perfluorohexanesulfonic acid |2 NLM | |
| 650 | 7 | |a 355-46-4 |2 NLM | |
| 650 | 7 | |a Hydrocarbons, Fluorinated |2 NLM | |
| 650 | 7 | |a Alkanesulfonic Acids |2 NLM | |
| 650 | 7 | |a Pesticides |2 NLM | |
| 700 | 1 | |a Grandjean, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Main, Katharina M |e verfasserin |4 aut | |
| 700 | 1 | |a Jensen, Tina Kold |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, Flemming |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of hygiene and environmental health |d 2000 |g 255(2023) vom: 06. Jan., Seite 114292 |w (DE-627)NLM108789403 |x 1618-131X |7 nnns |
| 773 | 1 | 8 | |g volume:255 |g year:2023 |g day:06 |g month:01 |g pages:114292 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijheh.2023.114292 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 255 |j 2023 |b 06 |c 01 |h 114292 | ||