Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus
© 2023. The Author(s)..
Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe2 minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation barrier of cis,cis-1,4-pentadiene moiety in the vesicle membrane. We showcase that the diatomic iron nanozyme can be incorporated into air purifier to disinfect airborne flu virus. The present strategy promises a future application in comprehensive biosecurity control.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Nature communications - 14(2023), 1 vom: 11. Nov., Seite 7312 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Li, Beibei [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Alkadienes |
|---|
| Anmerkungen: |
Date Completed 13.11.2023 Date Revised 22.11.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41467-023-43176-4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364436492 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364436492 | ||
| 003 | DE-627 | ||
| 005 | 20231226095429.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-023-43176-4 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1214.xml |
| 035 | |a (DE-627)NLM364436492 | ||
| 035 | |a (NLM)37951992 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Li, Beibei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.11.2023 | ||
| 500 | |a Date Revised 22.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe2 minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation barrier of cis,cis-1,4-pentadiene moiety in the vesicle membrane. We showcase that the diatomic iron nanozyme can be incorporated into air purifier to disinfect airborne flu virus. The present strategy promises a future application in comprehensive biosecurity control | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Lipoxygenase |2 NLM | |
| 650 | 7 | |a EC 1.13.11.12 |2 NLM | |
| 650 | 7 | |a Iron |2 NLM | |
| 650 | 7 | |a E1UOL152H7 |2 NLM | |
| 650 | 7 | |a Alkadienes |2 NLM | |
| 700 | 1 | |a Ma, Ruonan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Caiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yu-Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaonan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Helai |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Qikun |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Xiaobo |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jiarui |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Mengjuan |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Pengfei |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yanfen |e verfasserin |4 aut | |
| 700 | 1 | |a Che, Yizhen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chang |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Lizeng |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Zhiqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yadong |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 14(2023), 1 vom: 11. Nov., Seite 7312 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2023 |g number:1 |g day:11 |g month:11 |g pages:7312 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-023-43176-4 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2023 |e 1 |b 11 |c 11 |h 7312 | ||