InfluenCEF study : Clinical phenotype and duration of headache attributed to influenza infection
INTRODUCTION: Headache is a frequent symptom of infections. We aimed to characterize the clinical phenotype and duration of headache attributed to influenza infection.
METHODS: Prospective cohort study done in 53 primary care centers between January and April 2023. Patients were included if they had a confirmed influenza diagnosis, were older than 15 years and had a new-onset headache. Patients' demographics, prior medical history, headache phenotype and duration, associated symptoms and patients' outcomes were assessed. The International Classification of Headache Disorders criteria for headache attributed to a systemic viral infection, migraine and tension-type headache were assessed.
RESULTS: Of the 478 patients 75 fulfilled eligibility criteria. The mean age was 43, 56% were men, and 27% had a prior headache history. The headache phenotype was a bilateral headache (52%), with frontal topography (48%), pressing quality (61%), moderate intensity, rhinorrhea (79%), nasal congestion (76%), and photophobia (59%). All patients fulfilled headache attributed to acute systemic viral infection criteria, 43% fulfilled migraine criteria and 31% tension-type headache criteria. The median duration of the headache was four (Inter-quartile range: two-six) days.
CONCLUSION: The clinical phenotype of headache attributed to influenza infection was similar to other infections, with more pronounced cranial autonomic symptoms. The headache was an early symptom and was self-limited within a few days.Trial Registration: The study protocol is registered in ClinicalTrial.gov (NCT05704335).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cephalalgia : an international journal of headache - 43(2023), 11 vom: 11. Nov., Seite 3331024231212900 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
García-Azorín, David [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-inflammatory agents |
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| Anmerkungen: |
Date Completed 20.11.2023 Date Revised 27.11.2023 published: Print ClinicalTrials.gov: NCT05704335 Citation Status MEDLINE |
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| doi: |
10.1177/03331024231212900 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36442334X |
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| 100 | 1 | |a García-Azorín, David |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a InfluenCEF study |b Clinical phenotype and duration of headache attributed to influenza infection |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 27.11.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT05704335 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Headache is a frequent symptom of infections. We aimed to characterize the clinical phenotype and duration of headache attributed to influenza infection | ||
| 520 | |a METHODS: Prospective cohort study done in 53 primary care centers between January and April 2023. Patients were included if they had a confirmed influenza diagnosis, were older than 15 years and had a new-onset headache. Patients' demographics, prior medical history, headache phenotype and duration, associated symptoms and patients' outcomes were assessed. The International Classification of Headache Disorders criteria for headache attributed to a systemic viral infection, migraine and tension-type headache were assessed | ||
| 520 | |a RESULTS: Of the 478 patients 75 fulfilled eligibility criteria. The mean age was 43, 56% were men, and 27% had a prior headache history. The headache phenotype was a bilateral headache (52%), with frontal topography (48%), pressing quality (61%), moderate intensity, rhinorrhea (79%), nasal congestion (76%), and photophobia (59%). All patients fulfilled headache attributed to acute systemic viral infection criteria, 43% fulfilled migraine criteria and 31% tension-type headache criteria. The median duration of the headache was four (Inter-quartile range: two-six) days | ||
| 520 | |a CONCLUSION: The clinical phenotype of headache attributed to influenza infection was similar to other infections, with more pronounced cranial autonomic symptoms. The headache was an early symptom and was self-limited within a few days.Trial Registration: The study protocol is registered in ClinicalTrial.gov (NCT05704335) | ||
| 650 | 4 | |a Clinical Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Headache disorders | |
| 650 | 4 | |a anti-inflammatory agents | |
| 650 | 4 | |a migraine | |
| 650 | 4 | |a non-steroidal | |
| 650 | 4 | |a secondary | |
| 650 | 4 | |a virus diseases | |
| 700 | 1 | |a Santana-López, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Lozano-Alonso, José Eugenio |e verfasserin |4 aut | |
| 700 | 1 | |a Ordax-Díez, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a González-Osorio, Yésica |e verfasserin |4 aut | |
| 700 | 1 | |a Rojo-Rello, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Eiros, José M |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Martínez, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Recio-García, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Sierra-Mencía, Álvaro |e verfasserin |4 aut | |
| 700 | 1 | |a Sanz-Muñoz, Ivan |e verfasserin |4 aut | |
| 700 | 1 | |a Guerrero-Peral, Ángel Luis |e verfasserin |4 aut | |
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