An Easily Overlooked Disease : Hemophagocytic Syndrome
BACKGROUND: Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is a heterogenic syndrome, which leads to an acute, life-threatening inflammatory reaction. We report a case of rapid death due to HLH induced by chronic, active Epstein-Barr virus (EBV) infection.
METHODS: Appropriate laboratory tests, abdominal ultrasonography, and cervical lymph node biopsy.
RESULTS: Hemoglobin and platelet counts decreased, fasting triglyceride increased to 2.32 mmol/L, ferritin > 1,500 ng/mL, soluble CD25 (interleukin-2 receptor) > 2,400 U/mL, and abdominal ultrasound indicated splenomegaly, meeting the diagnostic criteria of HLH. A biopsy of the left cervical lymph node revealed chronic, active EBV infection.
CONCLUSIONS: HLH is likely under-recognized, and mortality remains high, especially in adults; thus, prompt diagnosis and treatment are essential.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Clinical laboratory - 69(2023), 11 vom: 01. Nov. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Yi [VerfasserIn] |
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| Anmerkungen: |
Date Completed 13.11.2023 Date Revised 13.11.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.7754/Clin.Lab.2023.230603 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM364401427 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is a heterogenic syndrome, which leads to an acute, life-threatening inflammatory reaction. We report a case of rapid death due to HLH induced by chronic, active Epstein-Barr virus (EBV) infection | ||
| 520 | |a METHODS: Appropriate laboratory tests, abdominal ultrasonography, and cervical lymph node biopsy | ||
| 520 | |a RESULTS: Hemoglobin and platelet counts decreased, fasting triglyceride increased to 2.32 mmol/L, ferritin > 1,500 ng/mL, soluble CD25 (interleukin-2 receptor) > 2,400 U/mL, and abdominal ultrasound indicated splenomegaly, meeting the diagnostic criteria of HLH. A biopsy of the left cervical lymph node revealed chronic, active EBV infection | ||
| 520 | |a CONCLUSIONS: HLH is likely under-recognized, and mortality remains high, especially in adults; thus, prompt diagnosis and treatment are essential | ||
| 650 | 4 | |a Case Reports | |
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| 700 | 1 | |a Gan, Yi L |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Tao |e verfasserin |4 aut | |
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