Laparoscopically Limited Anatomic Liver Resections : A Single-Center Analysis for Oncologic Outcomes of the Conceptual Procedure
© 2023. Society of Surgical Oncology..
BACKGROUND: Limited anatomic resections (LARs), such as segmentectomies, performed using a fully laparoscopic approach, have gained popularity for liver malignancies. However, the oncologic efficacy of laparoscopic LARs (Lap-LARs) needs further investigation. This cohort study evaluated the oncologic outcomes of Lap-LAR for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM).
METHODS: At a Japanese referral center, 112 patients underwent Lap-LAR using the Glissonean approach and indocyanine green (ICG) fluorescence navigation. Recurrence-free survival (RFS), overall survival (OS), time to interventional failure (TIF), and time to surgical failure (TSF) were assessed.
RESULTS: Among the 112 patients (median age, 74 years [range, 66-80 years]; 80 men [71.4 %]), Lap-LAR showed promising results. The median operative time was 348 min (range, 280-460 min), and the median blood loss was 190 mL (range, 95.5-452.0 mL). The median error between the estimated and actual liver volumes was 2 % (1.2-4.8 %). Complications greater than Clavien-Dindo 3a were observed in 11.6 % of the patients. The 5-year RFS, OS, and TIF rates for HCC were 45.1 % ± 7.9 %, 73.1 % ± 6.7 %, and 74.2 % ± 6 .6 %, respectively. The 5-year RFS, OS, and TSF rates for CRLM were 36.8 % ± 8.7 %, 60.1 % ± 13.3 %, and 63.6 % ± 10.4 %, respectively.
CONCLUSIONS: Lap-LAR showed favorable oncologic outcomes for HCC and CRLM. Its precise technique makes it a promising therapeutic option for liver malignancies. Further comparisons with conventional approaches are warranted.
| Errataetall: |
CommentIn: Ann Surg Oncol. 2024 Feb;31(2):1280-1281. - PMID 37991580 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Annals of surgical oncology - 31(2024), 2 vom: 13. Feb., Seite 1243-1251 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wakabayashi, Taiga [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal liver metastasis |
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| Anmerkungen: |
Date Completed 05.01.2024 Date Revised 12.03.2024 published: Print-Electronic CommentIn: Ann Surg Oncol. 2024 Feb;31(2):1280-1281. - PMID 37991580 Citation Status MEDLINE |
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| doi: |
10.1245/s10434-023-14462-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364396423 |
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| 500 | |a CommentIn: Ann Surg Oncol. 2024 Feb;31(2):1280-1281. - PMID 37991580 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. Society of Surgical Oncology. | ||
| 520 | |a BACKGROUND: Limited anatomic resections (LARs), such as segmentectomies, performed using a fully laparoscopic approach, have gained popularity for liver malignancies. However, the oncologic efficacy of laparoscopic LARs (Lap-LARs) needs further investigation. This cohort study evaluated the oncologic outcomes of Lap-LAR for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM) | ||
| 520 | |a METHODS: At a Japanese referral center, 112 patients underwent Lap-LAR using the Glissonean approach and indocyanine green (ICG) fluorescence navigation. Recurrence-free survival (RFS), overall survival (OS), time to interventional failure (TIF), and time to surgical failure (TSF) were assessed | ||
| 520 | |a RESULTS: Among the 112 patients (median age, 74 years [range, 66-80 years]; 80 men [71.4 %]), Lap-LAR showed promising results. The median operative time was 348 min (range, 280-460 min), and the median blood loss was 190 mL (range, 95.5-452.0 mL). The median error between the estimated and actual liver volumes was 2 % (1.2-4.8 %). Complications greater than Clavien-Dindo 3a were observed in 11.6 % of the patients. The 5-year RFS, OS, and TIF rates for HCC were 45.1 % ± 7.9 %, 73.1 % ± 6.7 %, and 74.2 % ± 6 .6 %, respectively. The 5-year RFS, OS, and TSF rates for CRLM were 36.8 % ± 8.7 %, 60.1 % ± 13.3 %, and 63.6 % ± 10.4 %, respectively | ||
| 520 | |a CONCLUSIONS: Lap-LAR showed favorable oncologic outcomes for HCC and CRLM. Its precise technique makes it a promising therapeutic option for liver malignancies. Further comparisons with conventional approaches are warranted | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal liver metastasis | |
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a Limited anatomic resection | |
| 650 | 4 | |a Liver malignancy | |
| 650 | 4 | |a Oncologic outcome | |
| 700 | 1 | |a Fujiyama, Yoshiki |e verfasserin |4 aut | |
| 700 | 1 | |a Mishima, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Igarashi, Kazuharu |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Berardi, Giammauro |e verfasserin |4 aut | |
| 700 | 1 | |a Alomari, Malek |e verfasserin |4 aut | |
| 700 | 1 | |a Colella, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Wakabayashi, Go |e verfasserin |4 aut | |
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