Association of lineage 4.2.2 of Mycobacterium tuberculosis with the 63-bp deletion variant of the mpt64 gene
IMPORTANCE: To date, rapid diagnostic methods based on the MPT64 antigen assay are increasingly utilized to differentiate between non-tuberculous mycobacteria and TB disease in clinical settings. Furthermore, numerous novel techniques based on the MPT64 release assay are continuously being developed and applied for the identification of both pulmonary and extrapulmonary TB. However, the diagnostic accuracy of the MPT64 antigen assay is influenced by the presence of 63 bp deletion variants within the mpt64 gene. To our knowledge, this is the first report on the association between the 63 bp deletion variant in mpt64 and Mycobacterium tuberculosis L4.2.2 globally, which highlights the need for the cautious utilization of MPT64-based testing in regions where L4.2.2 isolates are prevalent, such as China and Vietnam, and MPT64 negative results should be confirmed with another assay. In addition, further studies on vaccine development and immunology based on MPT64 should consider these isolates with 63 bp deletion variant.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Microbiology spectrum - 11(2023), 6 vom: 12. Dez., Seite e0184223 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Zexuan [VerfasserIn] |
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| Links: |
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| Themen: |
Antigens, Bacterial |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/spectrum.01842-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364390743 |
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| 520 | |a IMPORTANCE: To date, rapid diagnostic methods based on the MPT64 antigen assay are increasingly utilized to differentiate between non-tuberculous mycobacteria and TB disease in clinical settings. Furthermore, numerous novel techniques based on the MPT64 release assay are continuously being developed and applied for the identification of both pulmonary and extrapulmonary TB. However, the diagnostic accuracy of the MPT64 antigen assay is influenced by the presence of 63 bp deletion variants within the mpt64 gene. To our knowledge, this is the first report on the association between the 63 bp deletion variant in mpt64 and Mycobacterium tuberculosis L4.2.2 globally, which highlights the need for the cautious utilization of MPT64-based testing in regions where L4.2.2 isolates are prevalent, such as China and Vietnam, and MPT64 negative results should be confirmed with another assay. In addition, further studies on vaccine development and immunology based on MPT64 should consider these isolates with 63 bp deletion variant | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MPT64 antigen test | |
| 650 | 4 | |a Mycobacterium tuberculosis | |
| 650 | 4 | |a lineage L4.2.2 | |
| 650 | 4 | |a mpt64 | |
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| 700 | 1 | |a He, Wencong |e verfasserin |4 aut | |
| 700 | 1 | |a Pei, Shaojun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Xiaolong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yiting |e verfasserin |4 aut | |
| 700 | 1 | |a He, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Dongxin |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Aijing |e verfasserin |4 aut | |
| 700 | 1 | |a Ou, Xichao |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shengfen |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chunfa |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yanlin |e verfasserin |4 aut | |
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