Diverse biological functions of the renin-angiotensin system
© 2023 Wiley Periodicals LLC..
The renin-angiotensin system (RAS) has been widely known as a circulating endocrine system involved in the control of blood pressure. However, components of RAS have been found to be localized in rather unexpected sites in the body including the kidneys, brain, bone marrow, immune cells, and reproductive system. These discoveries have led to steady, growing evidence of the existence of independent tissue RAS specific to several parts of the body. It is important to understand how RAS regulates these systems for a variety of reasons: It gives a better overall picture of human physiology, helps to understand and mitigate the unintended consequences of RAS-inhibiting or activating drugs, and sets the stage for potential new therapies for a variety of ailments. This review fulfills the need for an updated overview of knowledge about local tissue RAS in several bodily systems, including their components, functions, and medical implications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
|---|---|
| Enthalten in: |
Medicinal research reviews - 44(2024), 2 vom: 06. Feb., Seite 587-605 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rao, Adithi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
11128-99-7 |
|---|
| Anmerkungen: |
Date Completed 07.02.2024 Date Revised 07.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/med.21996 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM364390166 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM364390166 | ||
| 003 | DE-627 | ||
| 005 | 20240207232112.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/med.21996 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1283.xml |
| 035 | |a (DE-627)NLM364390166 | ||
| 035 | |a (NLM)37947345 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rao, Adithi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diverse biological functions of the renin-angiotensin system |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 07.02.2024 | ||
| 500 | |a Date Revised 07.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Wiley Periodicals LLC. | ||
| 520 | |a The renin-angiotensin system (RAS) has been widely known as a circulating endocrine system involved in the control of blood pressure. However, components of RAS have been found to be localized in rather unexpected sites in the body including the kidneys, brain, bone marrow, immune cells, and reproductive system. These discoveries have led to steady, growing evidence of the existence of independent tissue RAS specific to several parts of the body. It is important to understand how RAS regulates these systems for a variety of reasons: It gives a better overall picture of human physiology, helps to understand and mitigate the unintended consequences of RAS-inhibiting or activating drugs, and sets the stage for potential new therapies for a variety of ailments. This review fulfills the need for an updated overview of knowledge about local tissue RAS in several bodily systems, including their components, functions, and medical implications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a ACE | |
| 650 | 4 | |a ACE2 | |
| 650 | 4 | |a Ang 1-7 | |
| 650 | 4 | |a Ang II | |
| 650 | 4 | |a hematopoiesis | |
| 650 | 4 | |a immune response | |
| 650 | 4 | |a renin-angiotensin system (RAS) | |
| 650 | 7 | |a Angiotensin II |2 NLM | |
| 650 | 7 | |a 11128-99-7 |2 NLM | |
| 650 | 7 | |a Peptidyl-Dipeptidase A |2 NLM | |
| 650 | 7 | |a EC 3.4.15.1 |2 NLM | |
| 700 | 1 | |a Bhat, Shabir A |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Giani, Jorge F |e verfasserin |4 aut | |
| 700 | 1 | |a Rader, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Bernstein, Kenneth E |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Zakir |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medicinal research reviews |d 1983 |g 44(2024), 2 vom: 06. Feb., Seite 587-605 |w (DE-627)NLM013079093 |x 1098-1128 |7 nnns |
| 773 | 1 | 8 | |g volume:44 |g year:2024 |g number:2 |g day:06 |g month:02 |g pages:587-605 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/med.21996 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 44 |j 2024 |e 2 |b 06 |c 02 |h 587-605 | ||