Transparency, openness, and reproducible research practices are frequently underused in health economic evaluations
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
OBJECTIVES: To investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness, and reproducibility.
STUDY DESIGN AND SETTING: We evaluated a random sample of health economic evaluations indexed in MEDLINE during 2019. We included articles written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years, and/or disability-adjusted life years. Reproducible research practices, openness, and transparency in each article were extracted in duplicate. We explored whether reproducible research practices were associated with self-report use of a guideline.
RESULTS: We included 200 studies published in 147 journals. Almost half were published as open access articles (n = 93; 47%). Most studies (n = 150; 75%) were model-based economic evaluations. In 109 (55%) studies, authors self-reported use a guideline (e.g., for study conduct or reporting). Few studies (n = 31; 16%) reported working from a protocol. In 112 (56%) studies, authors reported the data needed to recreate the incremental cost-effectiveness ratio for the base case analysis. This percentage was higher in studies using a guideline than studies not using a guideline (72/109 [66%] with guideline vs. 40/91 [44%] without guideline; risk ratio 1.50, 95% confidence interval 1.15-1.97). Only 10 (5%) studies mentioned access to raw data and analytic code for reanalyses.
CONCLUSION: Transparency, openness, and reproducible research practices are frequently underused in health economic evaluations. This study provides baseline data to compare future progress in the field.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:165 |
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| Enthalten in: |
Journal of clinical epidemiology - 165(2024) vom: 15. Jan., Seite 111208 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Catalá-López, Ferrán [VerfasserIn] |
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| Links: |
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| Themen: |
Cost-effectiveness analysis |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 13.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jclinepi.2023.10.024 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness, and reproducibility | ||
| 520 | |a STUDY DESIGN AND SETTING: We evaluated a random sample of health economic evaluations indexed in MEDLINE during 2019. We included articles written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years, and/or disability-adjusted life years. Reproducible research practices, openness, and transparency in each article were extracted in duplicate. We explored whether reproducible research practices were associated with self-report use of a guideline | ||
| 520 | |a RESULTS: We included 200 studies published in 147 journals. Almost half were published as open access articles (n = 93; 47%). Most studies (n = 150; 75%) were model-based economic evaluations. In 109 (55%) studies, authors self-reported use a guideline (e.g., for study conduct or reporting). Few studies (n = 31; 16%) reported working from a protocol. In 112 (56%) studies, authors reported the data needed to recreate the incremental cost-effectiveness ratio for the base case analysis. This percentage was higher in studies using a guideline than studies not using a guideline (72/109 [66%] with guideline vs. 40/91 [44%] without guideline; risk ratio 1.50, 95% confidence interval 1.15-1.97). Only 10 (5%) studies mentioned access to raw data and analytic code for reanalyses | ||
| 520 | |a CONCLUSION: Transparency, openness, and reproducible research practices are frequently underused in health economic evaluations. This study provides baseline data to compare future progress in the field | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cost-effectiveness analysis | |
| 650 | 4 | |a Data sharing | |
| 650 | 4 | |a Economic evaluation | |
| 650 | 4 | |a Methodology | |
| 650 | 4 | |a Quality | |
| 650 | 4 | |a Reporting | |
| 650 | 4 | |a Reproducibility | |
| 700 | 1 | |a Ridao, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Tejedor-Romero, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Caulley, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Hutton, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Husereau, Don |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso-Arroyo, Adolfo |e verfasserin |4 aut | |
| 700 | 1 | |a Bernal-Delgado, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Drummond, Michael F |e verfasserin |4 aut | |
| 700 | 1 | |a Moher, David |e verfasserin |4 aut | |
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