Undescribed compounds from Clinopodium chinense (Benth.) O. Kuntze and their coagulation activity studies
Copyright © 2023 Elsevier B.V. All rights reserved..
Four rare compounds (1-4), including one 1,4-epoxy-benzoxepane derivative and one ringed prenylated naphthoquinoid skeleton, as well as one isopimarane-type diterpenoid and one megastigmane-type glycoside, along with three known megastigmane-type glycosides (5-7) were isolated from the ethanol extracts of C. chinense. Their structures were determined on the basis of 1D, 2D NMR, HR-ESI-MS and DP4+ analysis. Meanwhile, the in vitro evaluation indicated that compound 2 and 6 exhibited excellent procoagulant activities, which can significantly shorten prothrombin time (PT) and activated partial thromboplastin time (APTT), respectively.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:172 |
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| Enthalten in: |
Fitoterapia - 172(2024) vom: 15. Jan., Seite 105736 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shen, Mingyi [VerfasserIn] |
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| Links: |
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| Themen: |
Clinopodium chinense (Benth.) Kuntze |
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| Anmerkungen: |
Date Completed 12.01.2024 Date Revised 12.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2023.105736 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Four rare compounds (1-4), including one 1,4-epoxy-benzoxepane derivative and one ringed prenylated naphthoquinoid skeleton, as well as one isopimarane-type diterpenoid and one megastigmane-type glycoside, along with three known megastigmane-type glycosides (5-7) were isolated from the ethanol extracts of C. chinense. Their structures were determined on the basis of 1D, 2D NMR, HR-ESI-MS and DP4+ analysis. Meanwhile, the in vitro evaluation indicated that compound 2 and 6 exhibited excellent procoagulant activities, which can significantly shorten prothrombin time (PT) and activated partial thromboplastin time (APTT), respectively | ||
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| 700 | 1 | |a Song, Huijie |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yumeng |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Dali |e verfasserin |4 aut | |
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