Role of affinity in plasma cell development in the germinal center light zone
© 2023 ElTanbouly et al..
Protective immune responses to many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in germinal centers (GCs). Transgenic models suggest that there is a stringent affinity-based barrier to PC development. Whether a similar high-affinity barrier regulates PC development under physiologic circumstances and the nature of the PC fate decision has not been defined precisely. Here, we use a fate-mapping approach to examine the relationship between GC B cells selected to undergo additional rounds of affinity maturation, GC pre-PC, and PC. The data show that initial PC selection overlaps with GC B cell selection, but that the PC compartment accumulates a less diverse and higher affinity collection of antibodies over time. Thus, whereas the GC continues to diversify over time, affinity-based pre-PC selection sieves the GC to enable the accumulation of a more restricted group of high-affinity antibody-secreting PC.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
The Journal of experimental medicine - 221(2024), 1 vom: 01. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
ElTanbouly, Mohamed A [VerfasserIn] |
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Date Completed 09.11.2023 Date Revised 10.02.2024 published: Print-Electronic ErratumIn: J Exp Med. 2024 Feb 5;221(2):. - PMID 38226977 Citation Status MEDLINE |
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| doi: |
10.1084/jem.20231838 |
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NLM364300930 |
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| 245 | 1 | 0 | |a Role of affinity in plasma cell development in the germinal center light zone |
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| 500 | |a ErratumIn: J Exp Med. 2024 Feb 5;221(2):. - PMID 38226977 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 ElTanbouly et al. | ||
| 520 | |a Protective immune responses to many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in germinal centers (GCs). Transgenic models suggest that there is a stringent affinity-based barrier to PC development. Whether a similar high-affinity barrier regulates PC development under physiologic circumstances and the nature of the PC fate decision has not been defined precisely. Here, we use a fate-mapping approach to examine the relationship between GC B cells selected to undergo additional rounds of affinity maturation, GC pre-PC, and PC. The data show that initial PC selection overlaps with GC B cell selection, but that the PC compartment accumulates a less diverse and higher affinity collection of antibodies over time. Thus, whereas the GC continues to diversify over time, affinity-based pre-PC selection sieves the GC to enable the accumulation of a more restricted group of high-affinity antibody-secreting PC | ||
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| 700 | 1 | |a Ramos, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a MacLean, Andrew J |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Spencer T |e verfasserin |4 aut | |
| 700 | 1 | |a Loewe, Maximilian |e verfasserin |4 aut | |
| 700 | 1 | |a Steinbach, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Ben Tanfous, Tarek |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Brianna |e verfasserin |4 aut | |
| 700 | 1 | |a Cipolla, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Gazumyan, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Thiago Y |e verfasserin |4 aut | |
| 700 | 1 | |a Nussenzweig, Michel C |e verfasserin |4 aut | |
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