An "AND" Logic-Gated Prodrug Micelle Locally Stimulates Antitumor Immunity
© 2023 Wiley-VCH GmbH..
Materials that can respond to multiple biomarkers simultaneously, acting as an "AND" gate, have the potential to enhance tumor-targeting for drug delivery. In this study, an "AND" logic-controlled release prodrug micelle is developed for codelivering the chemotherapeutic and the stimulator of interferon genes (STING) agonist, enabling precise combinatorial therapy. The drug release is programmed by tumor-enriched boramino acids (BAA) in the tumor microenvironment and intracellular reactive oxygen species (ROS), resulting in enhanced tumor targeting. STING agonist is successfully encapsulated into prodrug micelles through π-π stacking and hydrophobic interactions. These AND logic-gated prodrug micelles can achieve tumor-targeted delivery of STING agonist, leading to significantly enhanced immune activation and antitumor efficacy in vivo. It is expected that this clinically relevant nanoplatform will provide a rational design of an effective immunotherapy combination regimen to convert immunologically "cold" tumors to immunogenic "hot" tumors, addressing the major challenges faced by immunotherapies.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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Enthalten in: |
Advanced materials (Deerfield Beach, Fla.) - 36(2024), 6 vom: 06. Feb., Seite e2307818 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Chen, Mengqi [VerfasserIn] |
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Links: |
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Themen: |
AND logic |
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Anmerkungen: |
Date Completed 09.02.2024 Date Revised 09.02.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/adma.202307818 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM364269618 |
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700 | 1 | |a Liu, Zhibo |e verfasserin |4 aut | |
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