Pyrazole : an emerging privileged scaffold in drug discovery
Pyrazole or 1H-pyrazole, a five-membered 1,2-diazole, is found in several approved drugs and some bioactive natural products. A myriad number of derivatives of this small molecule have been reported in clinical and preclinical studies for the potential treatment of several diseases. The number of drugs containing a pyrazole nucleus has increased significantly in the last 10 years. Some of the best-selling drugs in this class are ibrutinib, ruxolitinib, axitinib, niraparib and baricitinib, and are used to treat different types of cancers; lenacapavir to treat HIV; riociguat to treat pulmonary hypertension; and sildenafil to treat erectile dysfunction. Several aniline-derived pyrazole compounds have been reported as potent antibacterial agents with selective activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Here, we discuss the pyrazole-derived drugs reported up to September 2023.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
---|---|
Enthalten in: |
Future medicinal chemistry - 15(2023), 21 vom: 07. Nov., Seite 2011-2023 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Alam, Mohammad Abrar [VerfasserIn] |
---|
Links: |
---|
Themen: |
3QD5KJZ7ZJ |
---|
Anmerkungen: |
Date Completed 15.11.2023 Date Revised 10.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.4155/fmc-2023-0207 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364254211 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM364254211 | ||
003 | DE-627 | ||
005 | 20240210232847.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.4155/fmc-2023-0207 |2 doi | |
028 | 5 | 2 | |a pubmed24n1287.xml |
035 | |a (DE-627)NLM364254211 | ||
035 | |a (NLM)37933613 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Alam, Mohammad Abrar |e verfasserin |4 aut | |
245 | 1 | 0 | |a Pyrazole |b an emerging privileged scaffold in drug discovery |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 15.11.2023 | ||
500 | |a Date Revised 10.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Pyrazole or 1H-pyrazole, a five-membered 1,2-diazole, is found in several approved drugs and some bioactive natural products. A myriad number of derivatives of this small molecule have been reported in clinical and preclinical studies for the potential treatment of several diseases. The number of drugs containing a pyrazole nucleus has increased significantly in the last 10 years. Some of the best-selling drugs in this class are ibrutinib, ruxolitinib, axitinib, niraparib and baricitinib, and are used to treat different types of cancers; lenacapavir to treat HIV; riociguat to treat pulmonary hypertension; and sildenafil to treat erectile dysfunction. Several aniline-derived pyrazole compounds have been reported as potent antibacterial agents with selective activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Here, we discuss the pyrazole-derived drugs reported up to September 2023 | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a MRSA | |
650 | 4 | |a antibacterial | |
650 | 4 | |a anticancer | |
650 | 4 | |a indazole | |
650 | 4 | |a kinase inhibitor | |
650 | 4 | |a lenacapavir | |
650 | 4 | |a pyrazole | |
650 | 4 | |a sildenafil | |
650 | 4 | |a zavegepant | |
650 | 7 | |a pyrazole |2 NLM | |
650 | 7 | |a 3QD5KJZ7ZJ |2 NLM | |
650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
650 | 7 | |a Pyrazoles |2 NLM | |
773 | 0 | 8 | |i Enthalten in |t Future medicinal chemistry |d 2009 |g 15(2023), 21 vom: 07. Nov., Seite 2011-2023 |w (DE-627)NLM194822109 |x 1756-8927 |7 nnns |
773 | 1 | 8 | |g volume:15 |g year:2023 |g number:21 |g day:07 |g month:11 |g pages:2011-2023 |
856 | 4 | 0 | |u http://dx.doi.org/10.4155/fmc-2023-0207 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 15 |j 2023 |e 21 |b 07 |c 11 |h 2011-2023 |