Regioselective Coupling of Different Conjugate Esters by Magnesium Metal Reduction : A Route to Unsymmetrical Adipic Acid Esters
A novel tactic to synthesize unsymmetrical 3-aryladipic acid esters has been developed via magnesium-promoted reductive coupling of ethyl cinnamates with methyl acrylate. In the present methodology, 3-aryladipic acid derivatives were prepared with good functional group tolerance and a wide substrate scope under very mild reaction conditions in good yields. The application of this reaction to dienic acid esters led to the successful control of the reaction to give 5-aryl-oct-3-enedioic acid esters with high regioselectivity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:88 |
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| Enthalten in: |
The Journal of organic chemistry - 88(2023), 22 vom: 17. Nov., Seite 15894-15901 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Tianyuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 17.11.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.joc.3c01982 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364249471 |
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| 245 | 1 | 0 | |a Regioselective Coupling of Different Conjugate Esters by Magnesium Metal Reduction |b A Route to Unsymmetrical Adipic Acid Esters |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A novel tactic to synthesize unsymmetrical 3-aryladipic acid esters has been developed via magnesium-promoted reductive coupling of ethyl cinnamates with methyl acrylate. In the present methodology, 3-aryladipic acid derivatives were prepared with good functional group tolerance and a wide substrate scope under very mild reaction conditions in good yields. The application of this reaction to dienic acid esters led to the successful control of the reaction to give 5-aryl-oct-3-enedioic acid esters with high regioselectivity | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Zhang, Jiawu |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Akihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Morii, Taku |e verfasserin |4 aut | |
| 700 | 1 | |a Kuramochi, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Maekawa, Hirofumi |e verfasserin |4 aut | |
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