Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats
© 2023. The Author(s)..
Compulsivity is considered a transdiagnostic dimension in obsessive-compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior on a schedule-induced polydipsia (SIP) task. Regional brain morphology was assessed using ex-vivo high-resolution magnetic resonance imaging (MRI). Voxel-based morphometry of segmented MRI images revealed larger white matter volumes in anterior commissure and corpus callosum of HD rats compared with LD rats. HD rats also showed significantly larger regional volumes of dorsolateral orbitofrontal cortex, striatum, amygdala, hippocampus, midbrain, sub-thalamic nucleus, and cerebellum. By contrast, the medial prefrontal cortex was significantly smaller in HD rats compared with LD rats with no significant group differences in whole brain, ventricular, or cerebrospinal fluid volumes. These findings show that limbic cortico-basal ganglia structures implicated in impulse control disorders are distinct in rats that are vulnerable to develop compulsive behavior. Such abnormalities may be relevant to the etiology of compulsive disorders in humans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Behavioral and brain functions : BBF - 19(2023), 1 vom: 06. Nov., Seite 19 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martín-González, Elena [VerfasserIn] |
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| Links: |
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| Themen: |
Compulsive behavior |
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| Anmerkungen: |
Date Completed 08.11.2023 Date Revised 10.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12993-023-00221-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364245921 |
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| 245 | 1 | 0 | |a Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats |
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| 500 | |a Date Revised 10.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Compulsivity is considered a transdiagnostic dimension in obsessive-compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior on a schedule-induced polydipsia (SIP) task. Regional brain morphology was assessed using ex-vivo high-resolution magnetic resonance imaging (MRI). Voxel-based morphometry of segmented MRI images revealed larger white matter volumes in anterior commissure and corpus callosum of HD rats compared with LD rats. HD rats also showed significantly larger regional volumes of dorsolateral orbitofrontal cortex, striatum, amygdala, hippocampus, midbrain, sub-thalamic nucleus, and cerebellum. By contrast, the medial prefrontal cortex was significantly smaller in HD rats compared with LD rats with no significant group differences in whole brain, ventricular, or cerebrospinal fluid volumes. These findings show that limbic cortico-basal ganglia structures implicated in impulse control disorders are distinct in rats that are vulnerable to develop compulsive behavior. Such abnormalities may be relevant to the etiology of compulsive disorders in humans | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Compulsive behavior | |
| 650 | 4 | |a Cortico-striatal-thalamic-cortical circuit | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Schedule-Induced Polydipsia | |
| 650 | 4 | |a Voxel-based morphometry | |
| 650 | 4 | |a White matter | |
| 700 | 1 | |a Prados-Pardo, Ángeles |e verfasserin |4 aut | |
| 700 | 1 | |a Sawiak, Stephen J |e verfasserin |4 aut | |
| 700 | 1 | |a Dalley, Jeffrey W |e verfasserin |4 aut | |
| 700 | 1 | |a Padro, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Cabrer, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Mora, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno-Montoya, Margarita |e verfasserin |4 aut | |
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