Biological and computational investigation of transition metal(II) complexes of 2-phenoxyaniline-based ligands
Aim: In the 21st century, we are witness of continuous onslaughts of various pathogen deformities which are a major cause of morbidity and mortality worldwide. Therefore, to investigate the grave for these deformities, antioxidant, anti-inflammatory and antimicrobial biological activities were carried out against newly synthesized Schiff base ligands and their transition metal complexes, which are based on newly synthesized 2-phenoxyaniline and salicylaldehyde derivatives. Materials & methods: The synthesized compounds were characterized by various physiochemical studies, demonstrating the octahedral stereochemistry of the complexes. Results: The biological assessments revealed that complex 6 (3.01 ± 0.01 μM) was found to be highly active for oxidant ailments whereas complex 14 (7.14 ± 0.05 μM, 0.0041-0.0082 μmol/ml) was observed as highly potent for inflammation and microbial diseases. Conclusion: Overall, the biological and computational studies demonstrate that the nickel(II) complex 14 can act as an excellent candidate for pathogen deformities.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Future medicinal chemistry - 15(2023), 21 vom: 06. Nov., Seite 1919-1942 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, Binesh [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.11.2023 Date Revised 16.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/fmc-2023-0046 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364214546 |
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| 100 | 1 | |a Kumar, Binesh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Biological and computational investigation of transition metal(II) complexes of 2-phenoxyaniline-based ligands |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 15.11.2023 | ||
| 500 | |a Date Revised 16.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: In the 21st century, we are witness of continuous onslaughts of various pathogen deformities which are a major cause of morbidity and mortality worldwide. Therefore, to investigate the grave for these deformities, antioxidant, anti-inflammatory and antimicrobial biological activities were carried out against newly synthesized Schiff base ligands and their transition metal complexes, which are based on newly synthesized 2-phenoxyaniline and salicylaldehyde derivatives. Materials & methods: The synthesized compounds were characterized by various physiochemical studies, demonstrating the octahedral stereochemistry of the complexes. Results: The biological assessments revealed that complex 6 (3.01 ± 0.01 μM) was found to be highly active for oxidant ailments whereas complex 14 (7.14 ± 0.05 μM, 0.0041-0.0082 μmol/ml) was observed as highly potent for inflammation and microbial diseases. Conclusion: Overall, the biological and computational studies demonstrate that the nickel(II) complex 14 can act as an excellent candidate for pathogen deformities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 2-phenoxyaniline ligand | |
| 650 | 4 | |a ADMET | |
| 650 | 4 | |a antimicrobial drugs | |
| 650 | 4 | |a biological activity | |
| 650 | 4 | |a characterization | |
| 650 | 4 | |a computational study | |
| 650 | 4 | |a salicylaldehyde derivative | |
| 650 | 4 | |a transition metal complex | |
| 650 | 7 | |a Transition Elements |2 NLM | |
| 650 | 7 | |a Nickel |2 NLM | |
| 650 | 7 | |a 7OV03QG267 |2 NLM | |
| 650 | 7 | |a Coordination Complexes |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Ligands |2 NLM | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Devi, Jai |e verfasserin |4 aut | |
| 700 | 1 | |a Dubey, Amit |e verfasserin |4 aut | |
| 700 | 1 | |a Tufail, Aisha |e verfasserin |4 aut | |
| 700 | 1 | |a Antil, Nidhi |e verfasserin |4 aut | |
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