Correlation between retinal sensitivity and retinal vascular perfusion after idiopathic epiretinal membrane peeling
BACKGROUND: To evaluate the correlations between anatomical and functional changes after idiopathic epiretinal membrane (iERM) surgery.
METHODS: In this prospective, observational, single-center study, consecutive patients who underwent iERM peeling were enrolled. Reported data were pre- and postoperative best-corrected visual acuity (BCVA), retinal sensitivity (RS) and fixation stability values on microperimetry, structural macular features on SD-OCT and OCTA. RS of foveal and parafoveal area was analysed and two sub-groups were identified whether RS improved or remained unchanged/worsened after surgery; consequently, vascular perfusion density (VPD) of the same area was studied.
RESULTS: Twenty-nine eyes of 29 patients were examined. The post-operative improvement in terms of BCVA, RS and fixation within the central 4 degrees was significant (p < 0.001, p < 0.001, p = 0.001), as well as the foveal thickness and macular volume change/reduction (p < 0.001). The pre-operative superficial VPD, choriocapillaris VPD and capillary free zone (CFZ) area were significantly reduced compared to the fellow healthy eye (p = 0.001, p = 0.02, p < 0.001). Choriocapillaris VPD showed a statistically significant increase after surgery (p < 0.02). Superficial, deep and choriocapillaris VPD of the improved RS group showed a significant increase both in foveal (p = 0.03, p = 0.03, p = 0.01) and parafoveal areas (p = 0.01, p = 0.03, p = 0.001).
CONCLUSIONS: We reported a higher VPD in the retinal area that experienced a retinal sensitivity improvement 6 months after ERM surgery. This result objectifies the tight bond between visual function and retinal perfusion in ERM patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
European journal of ophthalmology - (2023) vom: 05. Nov., Seite 11206721231212823 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nicolai, Michele [VerfasserIn] |
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| Links: |
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| Themen: |
Anatomy/biochemistry/physiology. |
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| Anmerkungen: |
Date Revised 06.11.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1177/11206721231212823 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM364188189 |
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| 100 | 1 | |a Nicolai, Michele |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Correlation between retinal sensitivity and retinal vascular perfusion after idiopathic epiretinal membrane peeling |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 06.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a BACKGROUND: To evaluate the correlations between anatomical and functional changes after idiopathic epiretinal membrane (iERM) surgery | ||
| 520 | |a METHODS: In this prospective, observational, single-center study, consecutive patients who underwent iERM peeling were enrolled. Reported data were pre- and postoperative best-corrected visual acuity (BCVA), retinal sensitivity (RS) and fixation stability values on microperimetry, structural macular features on SD-OCT and OCTA. RS of foveal and parafoveal area was analysed and two sub-groups were identified whether RS improved or remained unchanged/worsened after surgery; consequently, vascular perfusion density (VPD) of the same area was studied | ||
| 520 | |a RESULTS: Twenty-nine eyes of 29 patients were examined. The post-operative improvement in terms of BCVA, RS and fixation within the central 4 degrees was significant (p < 0.001, p < 0.001, p = 0.001), as well as the foveal thickness and macular volume change/reduction (p < 0.001). The pre-operative superficial VPD, choriocapillaris VPD and capillary free zone (CFZ) area were significantly reduced compared to the fellow healthy eye (p = 0.001, p = 0.02, p < 0.001). Choriocapillaris VPD showed a statistically significant increase after surgery (p < 0.02). Superficial, deep and choriocapillaris VPD of the improved RS group showed a significant increase both in foveal (p = 0.03, p = 0.03, p = 0.01) and parafoveal areas (p = 0.01, p = 0.03, p = 0.001) | ||
| 520 | |a CONCLUSIONS: We reported a higher VPD in the retinal area that experienced a retinal sensitivity improvement 6 months after ERM surgery. This result objectifies the tight bond between visual function and retinal perfusion in ERM patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Epiretinal membrane | |
| 650 | 4 | |a anatomy/biochemistry/physiology. | |
| 650 | 4 | |a pars plana vitrectomy | |
| 650 | 4 | |a retinal pathology / research | |
| 650 | 4 | |a techniques of retinal examination | |
| 700 | 1 | |a Franceschi, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a De Turris, Serena |e verfasserin |4 aut | |
| 700 | 1 | |a Rosati, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Carpenè, Maria Jolanda |e verfasserin |4 aut | |
| 700 | 1 | |a Danieli, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Lassandro, Nicola Vito |e verfasserin |4 aut | |
| 700 | 1 | |a Pelliccioni, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Lupidi, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Mariotti, Cesare |e verfasserin |4 aut | |
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