Mitochondrial dysfunction : a new molecular mechanism of intervertebral disc degeneration
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG..
OBJECTIVE: Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typical clinical symptom, severely reducing patients' quality of life and work efficiency, and imposing a significant economic burden on society. IVDD is defined by rapid extracellular matrix breakdown, nucleus pulposus cell loss, and an inflammatory response. It is intimately related to the malfunction or loss of myeloid cells among them. Many mechanisms have been implicated in the development of IVDD, including inflammatory factors, oxidative stress, apoptosis, cellular autophagy, and mitochondrial dysfunction. In recent years, mitochondrial dysfunction has become a hot research topic in age-related diseases. As the main source of adenosine triphosphate (ATP) in myeloid cells, mitochondria are essential for maintaining myeloid cell survival and physiological functions.
METHODS: We searched the PUBMED database with the search term "intervertebral disc degeneration and mitochondrial dysfunction" and obtained 82 articles, and after reading the abstracts and eliminating 30 irrelevant articles, we finally obtained 52 usable articles.
RESULTS: Through a review of the literature, it was discovered that IVDD and cellular mitochondrial dysfunction are also linked. Mitochondrial dysfunction contributes to the advancement of IVDD by influencing a number of pathophysiologic processes such as mitochondrial fission/fusion, mitochondrial autophagy, cellular senescence, and cell death.
CONCLUSION: We examine the molecular mechanisms of IVDD-associated mitochondrial dysfunction and present novel directions for quality management of mitochondrial dysfunction as a treatment approach to IVDD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
---|---|
Enthalten in: |
Inflammation research : official journal of the European Histamine Research Society ... [et al. - 72(2023), 12 vom: 16. Dez., Seite 2249-2260 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Song, Chao [VerfasserIn] |
---|
Links: |
---|
Themen: |
Autophagy |
---|
Anmerkungen: |
Date Completed 20.11.2023 Date Revised 20.11.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00011-023-01813-0 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364175133 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM364175133 | ||
003 | DE-627 | ||
005 | 20231226094902.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00011-023-01813-0 |2 doi | |
028 | 5 | 2 | |a pubmed24n1213.xml |
035 | |a (DE-627)NLM364175133 | ||
035 | |a (NLM)37925665 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Song, Chao |e verfasserin |4 aut | |
245 | 1 | 0 | |a Mitochondrial dysfunction |b a new molecular mechanism of intervertebral disc degeneration |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 20.11.2023 | ||
500 | |a Date Revised 20.11.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. | ||
520 | |a OBJECTIVE: Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typical clinical symptom, severely reducing patients' quality of life and work efficiency, and imposing a significant economic burden on society. IVDD is defined by rapid extracellular matrix breakdown, nucleus pulposus cell loss, and an inflammatory response. It is intimately related to the malfunction or loss of myeloid cells among them. Many mechanisms have been implicated in the development of IVDD, including inflammatory factors, oxidative stress, apoptosis, cellular autophagy, and mitochondrial dysfunction. In recent years, mitochondrial dysfunction has become a hot research topic in age-related diseases. As the main source of adenosine triphosphate (ATP) in myeloid cells, mitochondria are essential for maintaining myeloid cell survival and physiological functions | ||
520 | |a METHODS: We searched the PUBMED database with the search term "intervertebral disc degeneration and mitochondrial dysfunction" and obtained 82 articles, and after reading the abstracts and eliminating 30 irrelevant articles, we finally obtained 52 usable articles | ||
520 | |a RESULTS: Through a review of the literature, it was discovered that IVDD and cellular mitochondrial dysfunction are also linked. Mitochondrial dysfunction contributes to the advancement of IVDD by influencing a number of pathophysiologic processes such as mitochondrial fission/fusion, mitochondrial autophagy, cellular senescence, and cell death | ||
520 | |a CONCLUSION: We examine the molecular mechanisms of IVDD-associated mitochondrial dysfunction and present novel directions for quality management of mitochondrial dysfunction as a treatment approach to IVDD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Autophagy | |
650 | 4 | |a Intervertebral disc degeneration | |
650 | 4 | |a Mitochondrial dysfunction | |
650 | 4 | |a Nucleus pulposus cells | |
650 | 4 | |a Oxidative stress | |
700 | 1 | |a Xu, Yulin |e verfasserin |4 aut | |
700 | 1 | |a Peng, Qinghua |e verfasserin |4 aut | |
700 | 1 | |a Chen, Rui |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Daqian |e verfasserin |4 aut | |
700 | 1 | |a Cheng, Kang |e verfasserin |4 aut | |
700 | 1 | |a Cai, Weiye |e verfasserin |4 aut | |
700 | 1 | |a Liu, Tao |e verfasserin |4 aut | |
700 | 1 | |a Huang, Chenyi |e verfasserin |4 aut | |
700 | 1 | |a Fu, Zhijiang |e verfasserin |4 aut | |
700 | 1 | |a Wei, Cong |e verfasserin |4 aut | |
700 | 1 | |a Liu, Zongchao |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Inflammation research : official journal of the European Histamine Research Society ... [et al. |d 1997 |g 72(2023), 12 vom: 16. Dez., Seite 2249-2260 |w (DE-627)NLM075208601 |x 1420-908X |7 nnns |
773 | 1 | 8 | |g volume:72 |g year:2023 |g number:12 |g day:16 |g month:12 |g pages:2249-2260 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00011-023-01813-0 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 72 |j 2023 |e 12 |b 16 |c 12 |h 2249-2260 |