Weight and metabolic changes among virally suppressed people with HIV who switched to co-formulated bictegravir/emtricitabine/tenofovir alafenamide
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: We aimed to investigate the evolution of weight, lipid profiles, and glucose homeostasis among virally suppressed people with HIV (PWH) who switched to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF).
METHODS: PWH with viral suppression who switched to BIC/FTC/TAF in Taiwan between October 2019 and May 2021 were followed for 96 weeks to examine changes in weight, lipid profiles (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)), and glycated hemoglobin (HbA1c) levels.
RESULTS: 889 PWH with an average weight of 72.1 kg at baseline were included. At week 96, more than 95% of PWH consistently maintained plasma HIV RNA load <50 copies/mL at each 24-week interval of follow-up, while the weight change was small (+0.7 kg, P < 0.0001), although statistically significant. Baseline levels of TC, LDL-C, HDL-C, TG, and HbA1c were 191.8 mg/dL, 114.2 mg/dL, 48.9 mg/dL, 174.3 mg/dL, and 5.31%, respectively. After 96 weeks, changes were observed in TC (-11.6 mg/dL, P < 0.0001), LDL-C (-3.4 mg/dL, P = 0.0084), HDL-C (+0.6 mg/dL, P = 0.1089), TG (-30.2, P < 0.0001), and HbA1c (+0.12%, P < 0.0001). A 5% or more weight gain was associated with age of 30-40 years, normal weight at baseline, and prior use of non-integrase inhibitors or tenofovir disoproxil fumarate. Obesity was associated with development of both dyslipidaemia and diabetes mellitus after switch.
CONCLUSIONS: Stable switch to BIC/FTC/TAF maintained high rates of viral suppression and had a small effect on weight and metabolic changes in virally suppressed PWH. Follow-up of the weight and metabolic changes is warranted in PWH on long-term antiretroviral therapy.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
---|---|
Enthalten in: |
Journal of global antimicrobial resistance - 36(2024) vom: 22. März, Seite 426-435 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Hsu, Jen-Yu [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.jgar.2023.10.012 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364149817 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM364149817 | ||
003 | DE-627 | ||
005 | 20240325234350.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.jgar.2023.10.012 |2 doi | |
028 | 5 | 2 | |a pubmed24n1346.xml |
035 | |a (DE-627)NLM364149817 | ||
035 | |a (NLM)37923129 | ||
035 | |a (PII)S2213-7165(23)00181-9 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Hsu, Jen-Yu |e verfasserin |4 aut | |
245 | 1 | 0 | |a Weight and metabolic changes among virally suppressed people with HIV who switched to co-formulated bictegravir/emtricitabine/tenofovir alafenamide |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 25.03.2024 | ||
500 | |a Date Revised 25.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
520 | |a OBJECTIVES: We aimed to investigate the evolution of weight, lipid profiles, and glucose homeostasis among virally suppressed people with HIV (PWH) who switched to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) | ||
520 | |a METHODS: PWH with viral suppression who switched to BIC/FTC/TAF in Taiwan between October 2019 and May 2021 were followed for 96 weeks to examine changes in weight, lipid profiles (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)), and glycated hemoglobin (HbA1c) levels | ||
520 | |a RESULTS: 889 PWH with an average weight of 72.1 kg at baseline were included. At week 96, more than 95% of PWH consistently maintained plasma HIV RNA load <50 copies/mL at each 24-week interval of follow-up, while the weight change was small (+0.7 kg, P < 0.0001), although statistically significant. Baseline levels of TC, LDL-C, HDL-C, TG, and HbA1c were 191.8 mg/dL, 114.2 mg/dL, 48.9 mg/dL, 174.3 mg/dL, and 5.31%, respectively. After 96 weeks, changes were observed in TC (-11.6 mg/dL, P < 0.0001), LDL-C (-3.4 mg/dL, P = 0.0084), HDL-C (+0.6 mg/dL, P = 0.1089), TG (-30.2, P < 0.0001), and HbA1c (+0.12%, P < 0.0001). A 5% or more weight gain was associated with age of 30-40 years, normal weight at baseline, and prior use of non-integrase inhibitors or tenofovir disoproxil fumarate. Obesity was associated with development of both dyslipidaemia and diabetes mellitus after switch | ||
520 | |a CONCLUSIONS: Stable switch to BIC/FTC/TAF maintained high rates of viral suppression and had a small effect on weight and metabolic changes in virally suppressed PWH. Follow-up of the weight and metabolic changes is warranted in PWH on long-term antiretroviral therapy | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Antiretroviral therapy | |
650 | 4 | |a Diabetes mellitus | |
650 | 4 | |a Dyslipidaemia | |
650 | 4 | |a Integrase strand-transfer inhibitors | |
650 | 4 | |a Nucleotide reverse-transcriptase inhibitor | |
650 | 4 | |a Weight gain | |
650 | 7 | |a tenofovir alafenamide |2 NLM | |
650 | 7 | |a EL9943AG5J |2 NLM | |
650 | 7 | |a bictegravir |2 NLM | |
650 | 7 | |a 8GB79LOJ07 |2 NLM | |
650 | 7 | |a Anti-HIV Agents |2 NLM | |
650 | 7 | |a Emtricitabine |2 NLM | |
650 | 7 | |a G70B4ETF4S |2 NLM | |
650 | 7 | |a Cholesterol, LDL |2 NLM | |
650 | 7 | |a Glycated Hemoglobin |2 NLM | |
650 | 7 | |a Adenine |2 NLM | |
650 | 7 | |a JAC85A2161 |2 NLM | |
650 | 7 | |a Tenofovir |2 NLM | |
650 | 7 | |a 99YXE507IL |2 NLM | |
650 | 7 | |a Drug Combinations |2 NLM | |
650 | 7 | |a Piperazines |2 NLM | |
650 | 7 | |a Pyridones |2 NLM | |
650 | 7 | |a Alanine |2 NLM | |
650 | 7 | |a OF5P57N2ZX |2 NLM | |
650 | 7 | |a Amides |2 NLM | |
650 | 7 | |a Heterocyclic Compounds, 3-Ring |2 NLM | |
700 | 1 | |a Sun, Hsin-Yun |e verfasserin |4 aut | |
700 | 1 | |a Chen, Ling-Ya |e verfasserin |4 aut | |
700 | 1 | |a Chang, Sui-Yuan |e verfasserin |4 aut | |
700 | 1 | |a Chuang, Yu-Chung |e verfasserin |4 aut | |
700 | 1 | |a Huang, Yu-Shan |e verfasserin |4 aut | |
700 | 1 | |a Su, Yi-Ching |e verfasserin |4 aut | |
700 | 1 | |a Liu, Wen-Chun |e verfasserin |4 aut | |
700 | 1 | |a Hung, Chien-Ching |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of global antimicrobial resistance |d 2013 |g 36(2024) vom: 22. März, Seite 426-435 |w (DE-627)NLM237523876 |x 2213-7173 |7 nnns |
773 | 1 | 8 | |g volume:36 |g year:2024 |g day:22 |g month:03 |g pages:426-435 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jgar.2023.10.012 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 36 |j 2024 |b 22 |c 03 |h 426-435 |