A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc..
In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly excites forebrain areas that contribute to such functions (including the amygdala, basal forebrain and septum), but that the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there. We show that PCs directly inhibit parabrachial nuclei (PBN) neurons that project to numerous forebrain regions. Suppressing the PC-PBN pathway influences many regions in the forebrain and is aversive. Molecular profiling shows that PCs directly inhibit numerous types of PBN neurons that control diverse behaviors that are not involved in motor control. Therefore, the PC-PBN pathway allows the cerebellum to directly regulate activity in the forebrain, and may be an important substrate for cerebellar disorders arising from damage to the posterior vermis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Nature neuroscience - 26(2023), 11 vom: 02. Nov., Seite 1929-1941 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Christopher H [VerfasserIn] |
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| Anmerkungen: |
Date Completed 06.11.2023 Date Revised 10.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41593-023-01462-w |
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| PPN (Katalog-ID): |
NLM364114827 |
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| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Nature America, Inc. | ||
| 520 | |a In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly excites forebrain areas that contribute to such functions (including the amygdala, basal forebrain and septum), but that the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there. We show that PCs directly inhibit parabrachial nuclei (PBN) neurons that project to numerous forebrain regions. Suppressing the PC-PBN pathway influences many regions in the forebrain and is aversive. Molecular profiling shows that PCs directly inhibit numerous types of PBN neurons that control diverse behaviors that are not involved in motor control. Therefore, the PC-PBN pathway allows the cerebellum to directly regulate activity in the forebrain, and may be an important substrate for cerebellar disorders arising from damage to the posterior vermis | ||
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| 700 | 1 | |a Bond, Katherine E |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Dawei |e verfasserin |4 aut | |
| 700 | 1 | |a Nardone, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Vanderburg, Charles R |e verfasserin |4 aut | |
| 700 | 1 | |a Nadaf, Naeem M |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Zhiyi |e verfasserin |4 aut | |
| 700 | 1 | |a Mutume, Kefiloe |e verfasserin |4 aut | |
| 700 | 1 | |a Flaquer, Isabella |e verfasserin |4 aut | |
| 700 | 1 | |a Lowell, Bradford B |e verfasserin |4 aut | |
| 700 | 1 | |a Macosko, Evan Z |e verfasserin |4 aut | |
| 700 | 1 | |a Regehr, Wade G |e verfasserin |4 aut | |
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