Effectiveness of Biologic Agents Among Hispanic Patients With Metastatic Colorectal Cancer
Copyright © 2023 Elsevier Inc. All rights reserved..
BACKGROUND: Randomized clinical trials have defined the survival advantage with the addition of biologic drugs to chemotherapy in patients with metastatic colorectal cancer (mCRC). Under representation of Hispanics contributes to poorly defined outcomes in this group. We aim to determine whether the real-world benefit of biologics extends to Hispanics using a comparative effectiveness research approach.
METHODS: This retrospective cohort study included all treatment centers contributing to SEER registry with available claims in the SEER-Medicare linked database (2001-2011) and 2 hospitals (2004-2016) catering to minorities. Metastatic CRC patients were classified as receiving chemotherapy or biochemotherapy (CT plus biologics; if initiated within 3 months of chemotherapy). The primary outcome was overall survival (OS) among the Hispanic patients calculated from time of administration of first dose of chemotherapy to death or last follow-up. A weighted Cox regression model was used to assess differences in survival.
RESULTS: We identified 182 Hispanic patients with mCRC from the Patient Entitlement and Diagnosis Summary (PEDSF) file (n = 101) and hospital database (n = 81). Overall, 52% were women and 72% received biologics. The median OS was 11.3 and 17.0 months in chemotherapy and biochemotherapy group, respectively. Biochemotherapy offered a survival benefit compared with chemotherapy alone, with an average hazard rate reduction of 39% (95% CI 6%-60%, p = .0236) using inverse probability of treatment weighting (IPTW) based analysis.
CONCLUSION: In this cohort of Hispanic patients with mCRC, biochemotherapy was associated with longer survival. Clinicians may offer biochemotherapy therapy to all patients regardless of race/ethnicity to maximize clinical benefit.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
---|---|
Enthalten in: |
Clinical colorectal cancer - 23(2024), 1 vom: 01. März, Seite 14-21.e1 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Patel, Riya [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 05.03.2024 Date Revised 07.04.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.clcc.2023.10.001 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM364110554 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM364110554 | ||
003 | DE-627 | ||
005 | 20240407232241.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.clcc.2023.10.001 |2 doi | |
028 | 5 | 2 | |a pubmed24n1368.xml |
035 | |a (DE-627)NLM364110554 | ||
035 | |a (NLM)37919185 | ||
035 | |a (PII)S1533-0028(23)00089-0 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Patel, Riya |e verfasserin |4 aut | |
245 | 1 | 0 | |a Effectiveness of Biologic Agents Among Hispanic Patients With Metastatic Colorectal Cancer |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 05.03.2024 | ||
500 | |a Date Revised 07.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
520 | |a BACKGROUND: Randomized clinical trials have defined the survival advantage with the addition of biologic drugs to chemotherapy in patients with metastatic colorectal cancer (mCRC). Under representation of Hispanics contributes to poorly defined outcomes in this group. We aim to determine whether the real-world benefit of biologics extends to Hispanics using a comparative effectiveness research approach | ||
520 | |a METHODS: This retrospective cohort study included all treatment centers contributing to SEER registry with available claims in the SEER-Medicare linked database (2001-2011) and 2 hospitals (2004-2016) catering to minorities. Metastatic CRC patients were classified as receiving chemotherapy or biochemotherapy (CT plus biologics; if initiated within 3 months of chemotherapy). The primary outcome was overall survival (OS) among the Hispanic patients calculated from time of administration of first dose of chemotherapy to death or last follow-up. A weighted Cox regression model was used to assess differences in survival | ||
520 | |a RESULTS: We identified 182 Hispanic patients with mCRC from the Patient Entitlement and Diagnosis Summary (PEDSF) file (n = 101) and hospital database (n = 81). Overall, 52% were women and 72% received biologics. The median OS was 11.3 and 17.0 months in chemotherapy and biochemotherapy group, respectively. Biochemotherapy offered a survival benefit compared with chemotherapy alone, with an average hazard rate reduction of 39% (95% CI 6%-60%, p = .0236) using inverse probability of treatment weighting (IPTW) based analysis | ||
520 | |a CONCLUSION: In this cohort of Hispanic patients with mCRC, biochemotherapy was associated with longer survival. Clinicians may offer biochemotherapy therapy to all patients regardless of race/ethnicity to maximize clinical benefit | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Biologic therapy | |
650 | 4 | |a Chemotherapy | |
650 | 4 | |a Comparative effectiveness research | |
650 | 4 | |a Hispanics | |
650 | 4 | |a Survival outcome | |
650 | 7 | |a Biological Factors |2 NLM | |
650 | 7 | |a Biological Products |2 NLM | |
700 | 1 | |a Negassa, Abdissa |e verfasserin |4 aut | |
700 | 1 | |a Tolu, Seda S |e verfasserin |4 aut | |
700 | 1 | |a Acuna-Villaorduna, Ana |e verfasserin |4 aut | |
700 | 1 | |a Goel, Sanjay |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Clinical colorectal cancer |d 2000 |g 23(2024), 1 vom: 01. März, Seite 14-21.e1 |w (DE-627)NLM122314204 |x 1938-0674 |7 nnns |
773 | 1 | 8 | |g volume:23 |g year:2024 |g number:1 |g day:01 |g month:03 |g pages:14-21.e1 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.clcc.2023.10.001 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 23 |j 2024 |e 1 |b 01 |c 03 |h 14-21.e1 |